树突状细胞在分枝杆菌诱导的肉芽肿中的作用。
The role of dendritic cells in mycobacterium-induced granulomas.
机构信息
Department of Pathology and Laboratory Sciences, University of Wisconsin, Madison, WI 53705, USA.
出版信息
Immunol Lett. 2010 May 4;130(1-2):26-31. doi: 10.1016/j.imlet.2009.12.009. Epub 2010 Jan 4.
Abstract
The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infection. Potential functions may include mycobacterial dissemination from lesions or sampling of granuloma-containing mycobacterial antigens and migration to the draining lymph nodes to maintain continuous T cell priming. Additionally, the review will discuss the potential outcomes of DC-T cell cross-talk within the granuloma and whether it results in boosting the effector functions of newly arrived T cells or anergizing systemic T cells locally. Understanding the DCs complex and changing role during this critical stage may help explain how latency is achieved and maintained. Such knowledge might also lead to improved vaccination strategies.
摘要
树突状细胞（DCs）存在于含分枝杆菌的肉芽肿中，以及其他肉芽肿诱导性疾病中，这一点开始被人们所认识。这篇综述将总结关于 DCs 与肉芽肿相关的知识，并讨论 DCs 在分枝杆菌感染中可能发挥的潜在作用。潜在的功能可能包括分枝杆菌从病变部位的传播或分枝杆菌抗原的取样，以及迁移到引流淋巴结以维持持续的 T 细胞启动。此外，本综述还将讨论肉芽肿内 DC-T 细胞相互作用的潜在结果，以及这是否导致增强新到达的 T 细胞的效应功能，还是使局部的系统性 T 细胞失能。了解 DC 在这个关键阶段的复杂和不断变化的作用，可能有助于解释潜伏期是如何实现和维持的。这些知识也可能导致改进的疫苗接种策略。
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