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[单肺移植治疗终末期肺部疾病]

[Single lung transplantation as treatment of terminal lung diseases].

作者信息

Geiran O, Lindberg H, Frøysaker T, Svennevig J, Johansen B, Bjørtuft O, Naalsund A, Hysing E, Mohr B, Dragsund M

机构信息

Kirurgisk avdeling A, Rikshospitalet, Oslo.

出版信息

Tidsskr Nor Laegeforen. 1991 Jan 30;111(3):306-10.

PMID:2000609
Abstract

The article describes the first cases of single lung transplantation in Norway. The indication for surgery was end-stage pulmonary disease (1 sarcoidosis, 2 emphysema) in three severely disabled patients requiring administration of oxygen. The operation necessitated cardiopulmonary bypass in all patients. Primary graft function was excellent. Epidural analgesia, peripheral pulse oxymetry and continuous monitoring of mixed venous oxygen saturation aided early extubation. The initial postoperative course with a four drug immunosuppressive regimen has been encouraging. Rejection is monitored by clinical examination, chest x-ray, serial pulmonary function tests and transbronchial biopsies.

摘要

本文描述了挪威首例单肺移植病例。手术适应症为三名重度残疾且需要吸氧的终末期肺部疾病患者(1例结节病,2例肺气肿)。所有患者手术均需体外循环。移植肺原发性功能良好。硬膜外镇痛、外周脉搏血氧饱和度监测以及混合静脉血氧饱和度连续监测有助于早期拔管。采用四种药物免疫抑制方案的术后初期过程令人鼓舞。通过临床检查、胸部X光、系列肺功能测试以及经支气管活检监测排斥反应。

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