I 型干扰素作为 T 细胞和 B 细胞依赖的获得性免疫的免疫佐剂的介质。

Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity.

机构信息

Department of Pharmacology, Medical University of Vienna, Austria; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.

出版信息

Vaccine. 2009 Dec 30;27 Suppl 6:G17-20. doi: 10.1016/j.vaccine.2009.10.016.

DOI:10.1016/j.vaccine.2009.10.016

PMID:20006134

Abstract

Originally identified as antiviral substances produced by infected cells, type I interferons (IFN-I) are now known to have a wide range of additional activities within both the innate and adaptive immune response. Here we review properties of IFN-I contributing to their 'natural immune adjuvant' character, and their important role for the function of complete Freund's adjuvant (CFA) and the TLR9-dependent immune adjuvant IC31. We show data to demonstrate that treatment with IFN-I boosts the ability of vaccine/adjuvant combinations to induce peptide-specific CTL in both young and old mice. We view these findings in the perspective of previous clinical applications of IFN-I for vaccination.

摘要

最初被鉴定为受感染细胞产生的抗病毒物质，I 型干扰素（IFN-I）现在被认为在先天和适应性免疫反应中具有广泛的其他活性。在这里，我们回顾了 IFN-I 的特性，这些特性有助于其“天然免疫佐剂”特性，以及它们对完全弗氏佐剂（CFA）和 TLR9 依赖性免疫佐剂 IC31 的功能的重要作用。我们展示的数据表明，IFN-I 的治疗增强了疫苗/佐剂组合在年轻和老年小鼠中诱导肽特异性 CTL 的能力。我们从 IFN-I 以前用于疫苗接种的临床应用的角度来看待这些发现。