Modi Vivek, Krinock Matthew, Desai Ravi, Stevens Steven, Nanda Sudip
Cardiology, St. Luke's University Health Network, Bethlehem, USA.
Cardiology, Lehigh Valley Heart and Vascular Institute, Allentown, USA.
Cureus. 2021 Dec 27;13(12):e20744. doi: 10.7759/cureus.20744. eCollection 2021 Dec.
Reports of cardiac arrhythmia secondary to loperamide toxicity have become increasingly common in the literature. We present two patients in their mid-20s, each having overdosed on loperamide and subsequently manifesting life-threatening cardiac arrhythmias not otherwise explained by known pathology. An analysis of the limited research available indicates that loperamide's capacity to block ion channels may be responsible for these events. A better mechanistic understanding of loperamide's effects can help inform clinical management of patients with these life-threatening symptoms as at this time no set guidelines for management have yet been established.
文献中关于洛哌丁胺毒性继发心律失常的报道日益常见。我们报告了两名25岁左右的患者，他们均过量服用了洛哌丁胺，随后出现了已知病理无法解释的危及生命的心律失常。对现有有限研究的分析表明，洛哌丁胺阻断离子通道的能力可能是这些事件的原因。对洛哌丁胺作用机制有更深入的了解有助于指导对出现这些危及生命症状患者的临床管理，因为目前尚未制定既定的管理指南。
