Department of Epidemiology & Biostatistics, Texas A&M Health Science Center, School of Rural Public Health, College Station, TX 77843-1266, USA.
Ann Epidemiol. 2010 Jan;20(1):16-22. doi: 10.1016/j.annepidem.2009.09.011.
The relation between maternal pesticide exposures and neural tube defects (NTDs) in offspring was evaluated in 184 Mexican American case-women and 225 comparison women.
In-person interviews solicited information about environmental and occupational exposures to pesticides during the periconceptional period.
With adjustment for maternal education, smoking, and folate intake, women who reported using pesticides in their homes or yards were two times more likely (95% confidence interval [CI], 1.2-3.1) to have NTD-affected pregnancies than women without these reported exposures. Case-women were also more likely to report living within 0.25 mile of cultivated fields than control-women (odds ratio [OR] 3.6; 95% CI, 1.7-7.6). As sources of pesticide exposure opportunities increased, risk of NTDs also increased. The adjusted ORs and 95% CIs for one, two, and three or more exposure sources were 1.2 (0.69-1.9), 2.3 (1.3-4.1) and 2.8 (1.2-6.3) respectively, and this positive trend was stronger for risk of anencephaly than for spina bifida.
Self-reported pesticide exposures were associated with NTD risk in this study population, especially use of pesticides within the home and a periconceptional residence within 0.25 mile of cultivated fields.
评估 184 名墨西哥裔美国病例女性和 225 名对照女性在围孕期环境和职业暴露于农药与子女神经管缺陷 (NTD) 之间的关系。
通过面对面访谈，了解围孕期内家中和庭院使用农药的情况以及环境和职业农药暴露情况。
调整了母亲的教育、吸烟和叶酸摄入量后，报告在家中或庭院使用农药的女性发生 NTD 相关妊娠的可能性是未报告这些暴露的女性的两倍（95%置信区间 [CI]，1.2-3.1）。病例女性比对照女性更有可能报告住在种植田地 0.25 英里以内（比值比 [OR] 3.6；95%CI，1.7-7.6）。随着农药暴露机会源的增加，NTD 的风险也随之增加。调整后的 OR 和 95%CI 对于一个、两个和三个或更多暴露源的 NTD 风险分别为 1.2（0.69-1.9）、2.3（1.3-4.1）和 2.8（1.2-6.3），这种阳性趋势在无脑畸形风险方面比脊柱裂风险更为明显。
在本研究人群中，自我报告的农药暴露与 NTD 风险相关，尤其是在家中使用农药和围孕期内住在种植田地 0.25 英里以内。
