血清钙与前瞻性队列研究中的乳腺癌风险。
Serum calcium and breast cancer risk in a prospective cohort study.
机构信息
Department of Population Health Sciences and Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA.
出版信息
Ann Epidemiol. 2010 Jan;20(1):82-5. doi: 10.1016/j.annepidem.2009.09.001.
Abstract
Calcium has anti-proliferative and pro-differentiation effects on mammary cells in vitro and can inhibit the development of mammary tumors in mice. While there is some epidemiologic evidence for an inverse relation between dietary calcium intake and breast cancer risk, only one previous study has examined serum calcium levels in relation to breast cancer risk. We investigated this relation in a prospective cohort study of 2,762 women, aged 43-86, who were enrolled in the Beaver Dam Eye Study in 1988 and followed for up to 19 years. We found no evidence for an association between breast cancer risk and either total (hazard ratio, HR = 0.98; 95% CI: 0.60-1.60; 4(th) vs. 1(st) quartile) or ionized (HR = 0.85; 95% CI: 0.53, 1.38; 4(th) vs. 1(st) quartile) serum calcium levels. Additionally, we found no evidence for an association among subgroups defined by menopausal status and body mass index.
摘要
钙在体外对乳腺细胞具有抗增殖和促分化作用，并能抑制小鼠乳腺肿瘤的发展。虽然有一些流行病学证据表明饮食钙摄入量与乳腺癌风险之间存在反比关系，但之前只有一项研究检查了血清钙水平与乳腺癌风险之间的关系。我们在 1988 年参加比弗大坝眼研究的 2762 名年龄在 43-86 岁的女性前瞻性队列研究中调查了这种关系，并随访了长达 19 年。我们没有发现乳腺癌风险与总血清钙（危险比，HR = 0.98；95%置信区间：0.60-1.60；第 4 四分位数与第 1 四分位数）或离子化血清钙（HR = 0.85；95%置信区间：0.53,1.38；第 4 四分位数与第 1 四分位数）之间存在关联的证据。此外，我们在根据绝经状态和体重指数定义的亚组中也没有发现关联的证据。
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