Kesse-Guyot Emmanuelle, Bertrais Sandrine, Duperray Bernard, Arnault Nathalie, Bar-Hen Avner, Galan Pilar, Hercberg Serge
INSERM U557, INRA U1125, CNAM EA3200, Université Paris 13, CRNH IdF, Unité de Recherche en Epidémiologie Nutritionnelle, Bobigny, France.
Ann Nutr Metab. 2007;51(2):139-45. doi: 10.1159/000103274. Epub 2007 May 29.
The aim was to estimate the association between dairy products (total and their subgroups), calcium intake and the risk of breast cancer. As few studies have considered menopausal status, we also investigated stratified analyses. This analysis included 3,627 women from the French SU.VI.MAX study, among whom 92 developed breast cancer during the follow-up period. Food consumption was assessed based on five 24-hour records completed during the previous 18 months to follow-up. Calcium intake was calculated using an ad-hoc food composition database. Cox proportional hazards models were used to estimate relative risk (RR), comparing 4th quartile vs. 1st quartile, and 95% confidence intervals (95% CI). A lower risk of breast cancer was observed with high total dairy product consumption in the whole population (RR = 0.55, 95% CI = 0.29-1.03, p(trend) = 0.03) and among premenopausal women with a RR of 0.35 (95% CI = 0.12-0.95, p(trend) = 0.01). None of these associations remained after control for calcium intake. Increasing calcium intake was inversely associated with breast cancer risk considering the whole population (RR = 0.50, 95% CI = 0.27-0.91, p(trend) = 0.04) and among the subgroup of premenopausal women (RR = 0.26, 95% CI = 0.10-0.71, p(trend) = 0.01) respectively. Our data support the hypothesis that dairy products, through calcium content or a correlated component, might have a negative association with the risk of breast cancer, particularly among premenopausal women.
本研究旨在评估乳制品（总体及其亚组）、钙摄入量与乳腺癌风险之间的关联。由于很少有研究考虑绝经状态，我们还进行了分层分析。该分析纳入了法国SU.VI.MAX研究中的3627名女性，其中92名在随访期间患乳腺癌。根据随访前18个月内完成的5次24小时饮食记录评估食物摄入量。使用专门的食物成分数据库计算钙摄入量。采用Cox比例风险模型估计相对风险（RR），比较第4四分位数与第1四分位数，并计算95%置信区间（95%CI）。在整个人群中，高乳制品总摄入量与较低的乳腺癌风险相关（RR = 0.55，95%CI = 0.29 - 1.03，p趋势 = 0.03），在绝经前女性中RR为0.35（95%CI = 0.12 - 0.95，p趋势 = 0.01）。在控制钙摄入量后，这些关联均不再显著。考虑整个人群（RR = 0.50，95%CI = 0.27 - 0.91，p趋势 = 0.04）和绝经前女性亚组（RR = 0.26，95%CI = 0.10 - 0.71，p趋势 = 0.01）时，钙摄入量增加与乳腺癌风险呈负相关。我们的数据支持这样的假设，即乳制品通过其钙含量或相关成分，可能与乳腺癌风险呈负相关，尤其是在绝经前女性中。
