Steentoft A, Worm K
Københavns Universitet, Retskemisk Institut.
Ugeskr Laeger. 1991 Feb 11;153(7):500-3.
Benzodiazepines have been regarded as relatively "safe" drugs where fatal poisonings are concerned. The very potent benzodiazepines have, to a certain extent, changed this viewpoint and since triazolam was introduced in Denmark in 1978, six fatal intoxications have occurred in East Denmark. Triazolam analyses were performed by capillary gas chromatography with an electron capture detector. In the only case where no ethanol was present, a blood triazolam concentration of 0.3 mumol/kg was detected. In one case no blood was available because of putrefaction, and muscle was analysed for triazolam instead of blood. The concentration range in the four cases with an ethanol concentration of 1-2 mg/g is 0.1-0.6 mumol/kg. The blood concentrations from these six fatal intoxications are compared to blood concentrations from living persons. The whole blood concentrations from living persons were in the range 0.005-0.08 mumol/kg (n = 28) with an average concentration of 0.034 mumol/kg.
就致命中毒而言，苯二氮䓬类药物一直被视为相对“安全”的药物。药效极强的苯二氮䓬类药物在一定程度上改变了这一观点，自三唑仑于1978年在丹麦上市以来，丹麦东部已发生6起致命中毒事件。采用带有电子捕获检测器的毛细管气相色谱法对三唑仑进行分析。在唯一一例未检测到乙醇的病例中，检测到血液中三唑仑浓度为0.3微摩尔/千克。有一例因尸体腐败无法获取血液，故对肌肉而非血液进行了三唑仑分析。在乙醇浓度为1 - 2毫克/克的4例病例中，三唑仑浓度范围为0.1 - 0.6微摩尔/千克。将这6起致命中毒事件的血液浓度与活体人员的血液浓度进行比较。活体人员的全血浓度范围为0.005 - 0.08微摩尔/千克（n = 28），平均浓度为0.034微摩尔/千克。
