Charles University in Prague, Third Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague, Czech Republic.
Physiol Behav. 2010 Mar 3;99(3):381-7. doi: 10.1016/j.physbeh.2009.12.004. Epub 2009 Dec 18.
Methamphetamine (MA) is a drug causing potent psychomotor activation. The aim of the present study was: (1) to assess the effect of prenatal and acute MA administration on behavior in adult male rats and (2) to find out if the prenatal exposure to MA increases sensitivity to acute MA application in adulthood. Behavior of adult male rats prenatally exposed to MA (5mg/kg) or saline was tested in Open field (OF) and Elevated plus maze (EPM). Subcutaneously administered MA (1mg/kg) or saline were used as challenge in adulthood, 30 min prior to testing. Our results showed that prenatal MA did not have an effect on baseline behavior in either of the tests. By contrast, acute MA increased overall psychomotor activity by increasing locomotion and exploratory behavior and decreasing comforting behavior. Moreover, adult rats prenatally exposed to MA exhibited increased sniffing and decreased rearing after acute MA dose in adulthood relative to prenatally saline-exposed rats. In addition, while acute MA application decreased anxiety in rats prenatally exposed to MA, rats prenatally exposed to saline were less sensitive to the anxiolytic effects of MA. Our results indicate that changes caused by prenatal exposure to psychostimulants may become apparent as different reactivity to drugs of abuse when an individual encounters them later in life. In addition, we found that the anxiolytic effect of acute MA (1mg/kg) probably depends also on the reactivity to stress and the activity of hypothalamo-pituitary-adrenal axis.
甲基苯丙胺（MA）是一种能引起强烈精神运动激活的药物。本研究的目的是：（1）评估产前和急性 MA 给药对成年雄性大鼠行为的影响，（2）确定产前暴露于 MA 是否会增加成年期对急性 MA 应用的敏感性。通过对产前暴露于 MA（5mg/kg）或生理盐水的成年雄性大鼠进行旷场（OF）和高架十字迷宫（EPM）测试，评估其行为。皮下给予 MA（1mg/kg）或生理盐水作为挑战，在测试前 30 分钟给药。我们的结果表明，产前 MA 对两种测试中的基础行为均无影响。相比之下，急性 MA 通过增加运动和探索行为以及减少舒适行为，增加了整体精神运动活动。此外，与产前接受生理盐水暴露的大鼠相比，产前接受 MA 暴露的成年大鼠在接受急性 MA 剂量后表现出更多的嗅探行为和更少的后肢站立行为。此外，急性 MA 给药降低了产前暴露于 MA 的大鼠的焦虑，但对产前接受生理盐水暴露的大鼠的抗焦虑作用不敏感。我们的研究结果表明，产前暴露于精神兴奋剂引起的变化可能表现为个体以后遇到滥用药物时对其不同的反应性。此外，我们发现急性 MA（1mg/kg）的抗焦虑作用可能还取决于对压力的反应性和下丘脑-垂体-肾上腺轴的活性。
