野茼蒿中的倍半萜内酯及其对变异链球菌 ATCC 25175 的抑菌活性。
Sesquiterpene lactones from Sonchus arvensis L. and their antibacterial activity against Streptococcus mutans ATCC 25175.
机构信息
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China.
出版信息
Fitoterapia. 2010 Jul;81(5):424-8. doi: 10.1016/j.fitote.2009.12.001. Epub 2009 Dec 16.
Two new sesquiterpene lactones, 1beta-sulfate-5alpha, 6betaH-eudesma-3-en-12, 6alpha-olide (1) and 1beta-(p-hydroxyphenyl acetyl)-15-O-beta-D-glucopyranosyl-5alpha, 6betaH-eudesma-3-en-12, 6alpha-olide (2) were isolated from Sonchus arvensis L. (Asteraceae), together with eight known compounds. Their structures were elucidated through spectroscopic and chemical methods. They were evaluated for antibacterial activity. Among them, compounds 1 and 7 exhibited antibacterial activity against oral pathogen Streptococcus mutans ATCC 25175 with MIC values of 15.6 and 62.5 microg/ml, respectively.
从菊科植物苣荬菜(Sonchus arvensis L.)中分离得到两个新的倍半萜内酯化合物，1β-硫酸酯-5α，6βH-桉叶-3-烯-12，6α-内酯(1)和 1β-(对羟苯乙酰基)-15-O-β-D-吡喃葡萄糖基-5α，6βH-桉叶-3-烯-12，6α-内酯(2)，同时还分离得到了 8 个已知化合物。通过波谱和化学方法鉴定了它们的结构。对它们进行了抗菌活性评价。其中，化合物 1 和 7 对口腔病原菌变异链球菌(Streptococcus mutans ATCC 25175)具有抗菌活性，MIC 值分别为 15.6 和 62.5μg/ml。
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