来自凹叶羊蹄甲种子荚的抗菌倍半萜内酯糖苷。

Antibacterial sesquiterpene lactone glucoside from seed pods of Bauhinia retusa.

作者信息

Semwal Sushma, Sharma Rajni Kant

机构信息

Department of Chemistry, HNB Garhwal Central University Srinagar, Uttarakhand, India.

出版信息

J Asian Nat Prod Res. 2011 Jan;13(1):75-9. doi: 10.1080/10286020.2010.543130.

DOI:10.1080/10286020.2010.543130

PMID:21253953

Abstract

From the seed pods of Bauhinia retusa, a new eudesmane sesquiterpene glucoside, 1-O-β-D-glucopyranosyl-9β,15-dihydroxy-5α,6βH-eudesma-3-ene-6α,12-olide (1), has been isolated together with three known compounds, 4'-hydroxy-7-methoxy flavane (2), β-sitosterol (3), and stigmasterol (4). The structures of isolated compounds were verified with the help of 1D, 2D NMR, and HR-ESI-MS spectroscopies. Compound 1 showed moderate antibacterial activity against Pseudomonas aeruginosa and Escherichia coli when a disc diffusion method is used.

摘要

从毛叶羊蹄甲的种子荚中，分离出一种新的桉烷倍半萜糖苷1-O-β-D-吡喃葡萄糖基-9β,15-二羟基-5α,6βH-桉烷-3-烯-6α,12-内酯（1），以及三种已知化合物，4'-羟基-7-甲氧基黄烷（2）、β-谷甾醇（3）和豆甾醇（4）。借助一维、二维核磁共振和高分辨电喷雾电离质谱对分离得到的化合物结构进行了确证。采用纸片扩散法时，化合物1对铜绿假单胞菌和大肠杆菌显示出中等抗菌活性。