Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Semin Nephrol. 2009 Nov;29(6):579-86. doi: 10.1016/j.semnephrol.2009.07.004.
Aged people and rats have a reduced ability to maximally concentrate their urine. Many of the key transport proteins that contribute to urine concentrating ability are reduced in the medulla of aged rats. The reductions in the abundances of water, sodium, and urea transport proteins, and their reduced response to water restriction, contributes to the reduced ability of aged rats to concentrate their urine and conserve water. If similar mechanisms occur in human kidneys, it would provide a molecular explanation for the reduced concentrating ability in aging and may provide opportunities for novel therapeutic approaches to improve urine concentrating ability.
老年人和老鼠的尿液最大浓缩能力降低。许多有助于尿液浓缩能力的关键转运蛋白在老年大鼠的髓质中减少。水、钠和尿素转运蛋白的丰度降低，以及它们对水限制的反应性降低，导致老年大鼠浓缩尿液和保存水分的能力降低。如果类似的机制发生在人类肾脏中，它将为衰老时浓缩能力降低提供分子解释，并可能为改善尿液浓缩能力提供新的治疗方法的机会。
