Fujino Takahiro, Okamura Akiko, Hatsukawa Yoshikazu, Nakayama Keiko, Inoue Masami, Nakayama Masahiro
Department of Ophthalmology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.
J AAPOS. 2009 Dec;13(6):613-5. doi: 10.1016/j.jaapos.2009.09.016.
While yolk sac tumor is one of the most common malignant germ cell tumors occurring in young children, it is rarely found in extragonadal sites. We report a case of intraocular yolk sac tumor in a 4-year-old boy. The diagnosis was confirmed by histologic examination and by the rapid normalization of serum alpha-fetoprotein level following enucleation. We propose that yolk sac cells can potentially migrate into the eye at 22 days of embryonic life during neural tube formation, when the head and tail of the neuropore open contemporaneously and communicate with the amniotic cavity.
虽然卵黄囊瘤是幼儿最常见的恶性生殖细胞肿瘤之一，但在性腺外部位很少见。我们报告一例4岁男孩的眼内卵黄囊瘤。通过组织学检查以及眼球摘除术后血清甲胎蛋白水平迅速恢复正常得以确诊。我们认为，在胚胎发育22天时神经管形成过程中，当神经孔的头端和尾端同时开放并与羊膜腔相通时，卵黄囊细胞有可能迁移至眼内。
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