颞骨性腺外原发性卵黄囊瘤

Extragonadal primary yolk sac tumour of temporal bone.

作者信息

Narula Vineet, Meher Ravi, Rana Kanika, Sura Jaffer Husein, Nigam Jyotsana, Tandon Swati, Sharma Divya

机构信息

Department of ENT, BL Taneja block, Maulana Azad Medical College and Associated Lok Nayak, G.B. Pant and G.N.E.C. Hospitals, New Delhi 110002, India.

出版信息

Int J Pediatr Otorhinolaryngol. 2014 Aug;78(8):1416-8. doi: 10.1016/j.ijporl.2014.06.016. Epub 2014 Jun 20.

DOI:10.1016/j.ijporl.2014.06.016

PMID:24974145

Abstract

Yolk sac tumour, also known as endodermal sinus tumour (EST) is malignant germ cell tumours usually seen in children less than 3 years of age, involving the testis. We describe a rare case of extragonadal primary yolk sac tumour of the temporal bone in a 2.5 years old child presenting with a left sided post auricular mass and facial nerve palsy. Biopsy was consistent with yolk sac tumour showing expression of alpha fetoprotein. Patient was treated with chemotherapy including cisplatin, etoposide, and bleomycin. Post chemotherapy there was decrease in the swelling with improvement in facial nerve palsy.

摘要

卵黄囊瘤，也称为内胚窦瘤（EST），是一种恶性生殖细胞肿瘤，常见于3岁以下儿童，多累及睾丸。我们描述了一例罕见的颞骨性腺外原发性卵黄囊瘤病例，患儿2.5岁，表现为左耳后肿块和面神经麻痹。活检结果与卵黄囊瘤一致，显示甲胎蛋白表达。患者接受了包括顺铂、依托泊苷和博来霉素的化疗。化疗后肿胀减轻，面神经麻痹有所改善。