University of Michigan, Ann Arbor, MI 48109-5766, USA.
Int J Psychophysiol. 2010 Feb;75(2):211-5. doi: 10.1016/j.ijpsycho.2009.12.004. Epub 2009 Dec 13.
Major depressive disorder is associated with dysfunction in brain regions involved in language and emotion processing. Despite evidence of emotion processing biases in depression, neurophysiological evidence of language dysfunction for emotional words in depression has been inconsistent. This series of three studies evaluated whether depressed individuals exhibited abnormal semantic processing of emotionally-valenced words. During the passive viewing of sentences with mood congruent and incongruent sentence endings, the N400 component of the event-related brain potential was measured in patients with depression, dysthymia, or schizophrenia and in healthy controls. In each study, results revealed normal semantic processing in depression. That is, N400 was similar for both mood-incongruent (positive and neutral) endings and mood-congruent (negative) endings. In contrast, the small sample of individuals with schizophrenia exhibited a significantly exaggerated N400 for negative word endings compared to the depressed and healthy control groups. These data suggest anomalies in semantic network interactions with emotion processing in schizophrenia.
重度抑郁症与涉及语言和情绪处理的大脑区域功能障碍有关。尽管有抑郁情绪处理偏见的证据，但抑郁患者的情绪词语言功能障碍的神经生理学证据一直不一致。这一系列三项研究评估了抑郁患者是否表现出对情绪词汇的异常语义处理。在被动观看具有情绪一致和不一致句子结尾的句子时，对抑郁症、心境恶劣障碍或精神分裂症患者以及健康对照组进行事件相关脑电位的 N400 成分测量。在每项研究中，结果都显示抑郁患者的语义处理正常。也就是说，N400 对于情绪不一致（阳性和中性）的结尾和情绪一致（阴性）的结尾相似。相比之下，患有精神分裂症的个体样本数量较少，与抑郁组和健康对照组相比，他们对负性词结尾的 N400 明显夸大。这些数据表明，在精神分裂症中，语义网络与情绪处理的相互作用存在异常。
