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精神分裂症患者在处理脏话时语义网络的改变。

Alteration of Semantic Networks during Swear Words Processing in Schizophrenia.

作者信息

Lee Sang Won, Jeong Bumseok, Park Jong-Il, Chung Gyung Ho, Lee Hyo-Jong, Cui Yin, Kim Woo-Sung, Oh Kang Han, Oh Il Seok, Shen Guang Fan, Chung Young-Chul

机构信息

Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.

Center of Optics for Health Science, KAIST Institute, KAIST, Daejeon, Korea.

出版信息

Clin Psychopharmacol Neurosci. 2019 Feb 28;17(1):64-73. doi: 10.9758/cpn.2019.17.1.64.

DOI:10.9758/cpn.2019.17.1.64
PMID:30690941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6361040/
Abstract

OBJECTIVE

Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in patients with schizophrenia.

METHODS

In our study, 35 patients with schizophrenia and 19 healthy controls were recruited, and the participants were asked to passively view the words that contained swearing and neutral content during functional magnetic resonance imaging.

RESULTS

Patients with schizophrenia, compared to healthy controls, showed hypoactivation to the swear and neutral words stimuli in the left inferior frontal gyrus, left middle frontal gyrus, and left angular/supramarginal gyrus. More specifically, patients with remitted schizophrenia were found to have greater activation to the stimuli in the left middle/inferior frontal gyrus than patients with active schizophrenia. Furthermore, in the analysis of regions of interests, the left inferior and middle frontal gyrus activity was related to the severity of positive symptoms, including delusion and suspiciousness.

CONCLUSION

Our results suggest that patients with schizophrenia have difficulty in semantic processing and inhibitory control of swear words, and these abnormalities may be connected with the severity of positive symptoms.

摘要

目的

诸如妄想和幻觉等阳性症状在精神分裂症中通常包含负面情绪内容。我们研究了精神分裂症患者在处理强烈负面情绪词汇过程中涉及的神经基础。

方法

在我们的研究中，招募了35名精神分裂症患者和19名健康对照者，参与者在功能磁共振成像期间被要求被动观看包含咒骂和中性内容的词汇。

结果

与健康对照者相比，精神分裂症患者在左侧额下回、左侧额中回和左侧角回/缘上回对咒骂和中性词汇刺激表现出激活不足。更具体地说，发现缓解期精神分裂症患者在左侧额中/下回对刺激的激活程度高于活动期精神分裂症患者。此外，在感兴趣区域分析中，左侧额下回和额中回的活动与包括妄想和猜疑在内的阳性症状严重程度相关。

结论

我们的结果表明，精神分裂症患者在咒骂词汇的语义处理和抑制控制方面存在困难，这些异常可能与阳性症状的严重程度有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/f04c108981a7/cpn-17-064f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/a533a4f80bdf/cpn-17-064f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/12fd176e86d1/cpn-17-064f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/82d235930260/cpn-17-064f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/ec79f807aebe/cpn-17-064f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/f04c108981a7/cpn-17-064f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/a533a4f80bdf/cpn-17-064f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/12fd176e86d1/cpn-17-064f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/82d235930260/cpn-17-064f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/ec79f807aebe/cpn-17-064f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2557/6361040/f04c108981a7/cpn-17-064f5.jpg

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