Hintze G, Windeler J, Baumert J, Stein H, Köbberling J
Department of Medicine, Ferdinand-Sauerbruch-Hospital, Wuppertal, FRG.
Acta Endocrinol (Copenh). 1991 Jan;124(1):12-8. doi: 10.1530/acta.0.1240012.
In 569 unselected elderly subjects over 60 years from the general population of an iodine-deficient area, a palpation and an ultrasound investigation of the thyroid were performed. Additionally, thyroid hormone values were determined in 466 of the 569 subjects (81.9%) and urinary iodine excretion in 491 subjects (86.3%). By palpation, no thyroid enlargement was noticed in 302 subjects (54.2%), goitre Ia in 98 (17.6%), goitre Ib in 94 (16.9%), goitre II in 53 (9.5%), and goitre III in 10 (1.8%). The thyroid volumes (medians) by ultrasound were 18.6 ml in the entire group, in women (N = 489) 19.2 ml, and in men (N = 80) 16.6 ml. One hundred and one subjects had a thyroid nodule (17.6%), 43 persons cystic lesions (7.6%). If, according to the literature, a goitre is defined as a thyroid enlargement of more than 18 ml in women and more than 25 ml in males, a goitre prevalence of 54.2% in females and of 22.5% in males was obtained. The goitre prevalence in the entire group was calculated as 49.7%. Thyroid hormone measurements showed in subjects with goitre a significant lower TSH value (p less than 0.001) and a higher thyroglobulin value (p less than 0.001). In summary, the study shows a high prevalence of goitre in elderly subjects, a high prevalence of nodules in these thyroids, a negative correlation of goitre volume with TSH, and a positive correlation of goitre volume with the thyroglobulin concentration.
在一个碘缺乏地区的普通人群中，对569名60岁以上未经过挑选的老年人进行了甲状腺触诊和超声检查。此外，对569名受试者中的466名（81.9%）测定了甲状腺激素值，对491名受试者（86.3%）测定了尿碘排泄量。通过触诊，302名受试者（54.2%）未发现甲状腺肿大，98名（17.6%）为Ia级甲状腺肿，94名（16.9%）为Ib级甲状腺肿，53名（9.5%）为II级甲状腺肿，10名（1.8%）为III级甲状腺肿。超声检查显示，整个组的甲状腺体积（中位数）为18.6毫升，女性（N = 489）为19.2毫升，男性（N = 80）为16.6毫升。101名受试者有甲状腺结节（17.6%），43人有囊性病变（7.6%）。根据文献，如果将甲状腺肿定义为女性甲状腺肿大超过18毫升、男性超过25毫升，那么女性甲状腺肿患病率为54.2%，男性为22.5%。整个组的甲状腺肿患病率经计算为49.7%。甲状腺激素测量显示，甲状腺肿患者的促甲状腺激素（TSH）值显著降低（p < 0.001），甲状腺球蛋白值升高（p < 0.001）。总之，该研究表明老年受试者中甲状腺肿患病率高，这些甲状腺中结节患病率高，甲状腺肿体积与TSH呈负相关，与甲状腺球蛋白浓度呈正相关。
