手性硅胶整体柱在色谱法和胶束电动色谱法中的应用。

Chiral silica-based monoliths in chromatography and capillary electrochromatography.

机构信息

Institute of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany.

出版信息

J Chromatogr A. 2010 Feb 12;1217(7):941-52. doi: 10.1016/j.chroma.2009.11.079. Epub 2009 Dec 2.

DOI:10.1016/j.chroma.2009.11.079

PMID:20006990

Abstract

Chiral-modified silica-based monoliths have become well-established stationary phases for both high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). The silica-based monoliths were fabricated either in situ in the capillaries for nano-HPLC and CEC or in a mould for "conventional" HPLC. The present review summarizes the chiral modification of silica monoliths and the recent development in the field of enantioselective separations by nano-HPLC and CEC.

摘要

手性改性硅胶整体柱已成为高效液相色谱（HPLC）和毛细管电色谱（CEC）中应用广泛的固定相。硅胶整体柱可以通过原位聚合在毛细管内制备用于纳升级 HPLC 和 CEC，也可以在模具中制备用于“常规”HPLC。本文综述了硅胶整体柱的手性改性及其在手性拆分领域的最新进展，包括纳升级 HPLC 和 CEC。