Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA.
J Clin Microbiol. 2010 Feb;48(2):539-44. doi: 10.1128/JCM.01505-09. Epub 2009 Dec 9.
Cryptococcus gattii emerged in North America in 1999 as a human and veterinary pathogen on Vancouver Island, British Columbia. The emergent subtype, VGIIa, and the closely related subtype VGIIb can now be found in the United States in Washington, Oregon, and California. We performed multilocus sequence typing and antifungal susceptibility testing on 43 isolates of C. gattii from human patients in Oregon, Washington, California, and Idaho. In contrast to Vancouver Island, VGIIa was the most frequent but not the predominant subtype in the northwest United States. Antifungal susceptibility testing showed statistically significant differences in MICs between the subtypes. This is the first study to apply antifungal susceptibility testing to C. gattii isolates from the Pacific Northwest and the first to make direct comparisons between subtypes.
隐球菌 gattii 于 1999 年出现在北美的不列颠哥伦比亚省温哥华岛，成为人类和兽医病原体。新兴的亚型 VGIIa 和密切相关的亚型 VGIIb 现在可以在美国华盛顿州、俄勒冈州和加利福尼亚州找到。我们对来自俄勒冈州、华盛顿州、加利福尼亚州和爱达荷州的 43 例人类患者的隐球菌 gattii 进行了多位点序列分型和抗真菌药敏试验。与温哥华岛不同，VGIIa 虽然是最常见的亚型，但不是美国西北部的主要亚型。抗真菌药敏试验显示，各亚型之间 MIC 值存在统计学显著差异。这是首次将抗真菌药敏试验应用于太平洋西北地区的隐球菌 gattii 分离株的研究，也是首次对各亚型进行直接比较的研究。
