Poplin Victoria, Smith Clarissa, Caceres Diego H, Herkert Patricia F, Jegede Olujimi, Thompson George R, Baddley John W, Schwartz Ilan S, Kubat Ryan, Deka Mark A, Toda Mitsuru, Lockhart Shawn R, Chiller Tom, Hagen Ferry, Bahr Nathan C
Division of Infectious Diseases, Department of Medicine, University of Kansas, Kansas City, KS, USA.
Department of Internal Medicine, University of Kansas, Kansas City, KS, USA; Section of Pulmonary/Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA.
Lancet Microbe. 2024 Dec;5(12):100921. doi: 10.1016/S2666-5247(24)00161-7. Epub 2024 Aug 24.
The taxonomy of the Cryptococcus gattii species complex continues to evolve, and has been divided into five pathogenic species. The objective of this systematic review was to summarise the geographical distribution of the C gattii species complex and the species within the C gattii species complex. We searched PubMed for articles related to human, animal, ecological, or laboratory-based studies of C gattii species complex isolates with traceable geographical origin published from January, 1970, until September, 2021. Having extracted their geographical origin, we used ArcMap to construct maps according to the highest degree of resolution allowed by their reported taxonomy, to reflect the most likely area of transmission on the basis of published reports of human isolates. 604 such articles were included in the study. This review indicated that although C gattii species complex isolates have been reported globally, understanding their heterogeneous geographical distribution by species can have implications for researchers and clinicians in formulating research questions and considering diagnostic quandaries.
加氏隐球菌复合种的分类学仍在不断发展，现已分为五个致病菌种。本系统评价的目的是总结加氏隐球菌复合种及其所含菌种的地理分布情况。我们在PubMed上搜索了1970年1月至2021年9月发表的与加氏隐球菌复合种分离株的人类、动物、生态学或实验室研究相关的文章，这些分离株的地理来源可追溯。提取其地理来源后，我们使用ArcMap根据所报告分类学允许的最高分辨率构建地图，以根据已发表的人类分离株报告反映最可能的传播区域。该研究纳入了604篇此类文章。本综述表明，尽管加氏隐球菌复合种分离株在全球均有报道，但按菌种了解其异质性地理分布可能会对研究人员和临床医生在制定研究问题和考虑诊断难题方面产生影响。
