Frelin C
Institut de Pharmacologie Moléculaire et Cellulaire du CNRS, Université de Nice.
Am Heart J. 1991 Mar;121(3 Pt 1):958-60. doi: 10.1016/0002-8703(91)90226-8.
The contractility of vascular smooth muscle cells is controlled in a complex manner by both extracellular and intracellular messages. The vascular endothelium does not simply act as a physical barrier between the blood and smooth muscle cells, it integrates intravascular signals and controls the contractility of underlying smooth muscle cells by way of release of paracrine factors with contracting or relaxing properties. Vasoconstrictors trigger a cascade of interacting intracellular signals that concur in initiating and maintaining contractions. Each step of these signalling pathways is a possible logical site for potential therapeutic interventions.
血管平滑肌细胞的收缩性受细胞外和细胞内信息以复杂方式控制。血管内皮不仅仅是血液与平滑肌细胞之间的物理屏障，它整合血管内信号，并通过释放具有收缩或舒张特性的旁分泌因子来控制其下方平滑肌细胞的收缩性。血管收缩剂引发一系列相互作用的细胞内信号，这些信号共同启动并维持收缩。这些信号通路的每一步都是潜在治疗干预的可能逻辑位点。
