Koubský K
Cesk Fysiol. 2015;64(1):19-22.
Hypoxic pulmonary vasoconstriction is a means of optimising the oxygenation of blood in the lungs by redistributing the flow from poorly ventilated areas into well ventilated ones. It is caused by a direct effect of hypoxia on pulmonary vascular smooth muscle cells. For a vascular smooth muscle cell to contract, an increased intracellular concentration of calcium is needed. However, the contraction force can also be regulated independently of calcium concentration by calcium sensitivity. The sensitivity is regulated mainly by activation/deactivation of myosin light chain phosphatase. Several metabolic pathways converge on this enzyme. The increase in calcium sensitivity is an important process during hypoxic pulmonary vasoconstriction.
缺氧性肺血管收缩是一种通过将血流从通气不良区域重新分配到通气良好区域来优化肺部血液氧合的方式。它是由缺氧对肺血管平滑肌细胞的直接作用引起的。血管平滑肌细胞要收缩，就需要细胞内钙浓度增加。然而，收缩力也可以通过钙敏感性独立于钙浓度进行调节。这种敏感性主要由肌球蛋白轻链磷酸酶的激活/失活来调节。几种代谢途径都作用于这种酶。钙敏感性增加是缺氧性肺血管收缩过程中的一个重要过程。
