Scott J P, Higenbottam T W, Hutter J A, Large S, Wallwork J
Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge, England.
Am J Cardiol. 1991 Mar 15;67(7):628-32. doi: 10.1016/0002-9149(91)90903-x.
The effect of cyclosporine on the systemic circulation and on heart rate is unknown for heart transplant recipients. Thirty-four heart transplant recipients were studied by right-sided cardiac catheterization after endomyocardial biopsy. A direct linear relation was found between systemic and pulmonary vascular resistance and cyclosporine trough blood levels, which were negatively related to heart rate. The effect of cyclosporine on pulmonary vascular resistance, however, was not statistically significant by multivariate analysis when patient age was considered. In contrast, renal function appeared unrelated to systemic vascular resistance or heart rate. It appears that cyclosporine trough blood levels may have a direct effect on systemic vascular resistance as well as an unexplained negative chronotropic effect on heart rate.
环孢素对心脏移植受者体循环和心率的影响尚不清楚。对34例心脏移植受者在心肌内膜活检后进行了右侧心导管检查。发现体循环和肺血管阻力与环孢素谷血浓度之间存在直接线性关系，而环孢素谷血浓度与心率呈负相关。然而，在考虑患者年龄时，多变量分析显示环孢素对肺血管阻力的影响无统计学意义。相比之下，肾功能似乎与体循环血管阻力或心率无关。看来环孢素谷血浓度可能对体循环血管阻力有直接影响，以及对心率有无法解释的负性变时作用。
