Verkade H J, Hoving E B, Muskiet F A, Martini I A, Jansen G, Okken A, Vonk R J, Bijleveld C M
Department of Pediatrics, University of Groningen, The Netherlands.
Am J Clin Nutr. 1991 Mar;53(3):643-51. doi: 10.1093/ajcn/53.3.643.
We studied malabsorption of fat in neonates who were fed either a lard-modified formula (n = 22, gestational age, 33.6 +/- 3.9 wk) or an unmodified formula (n = 14, gestational age, 34.1 +/- 3.7 wk). In both groups fecal lipid consisted almost completely (greater than 90%) of free fatty acids, whose composition was highly correlated with the corresponding formula's fatty acid composition [r = 0.96 (lard modified) and r = 0.99 (standard)]. Both groups had similar relative amounts and compositions of fecal cholesterol esters and triglycerides. Plasma and, to a lesser extent, erythrocyte membrane long-chain-fatty-acid compositions correlated with those of the corresponding formulas. We suggest that the extensive intestinal hydrolysis and limited absorption of dietary lipids is, at least partly, due to lipolysis in the colon. Appearance of triglycerides in the colon may be due to a rapid small-intestinal passage in relation to small-intestinal lipolysis.
我们研究了喂食猪油改良配方奶粉（n = 22，胎龄33.6±3.9周）或未改良配方奶粉（n = 14，胎龄34.1±3.7周）的新生儿的脂肪吸收不良情况。两组粪便脂质几乎完全（>90%）由游离脂肪酸组成，其组成与相应配方奶粉的脂肪酸组成高度相关[r = 0.96（猪油改良）和r = 0.99（标准）]。两组粪便胆固醇酯和甘油三酯的相对含量和组成相似。血浆以及在较小程度上红细胞膜长链脂肪酸组成与相应配方奶粉的组成相关。我们认为，膳食脂质在肠道的广泛水解和有限吸收至少部分是由于结肠中的脂肪分解。结肠中甘油三酯的出现可能是由于相对于小肠脂肪分解而言小肠通过速度较快。
