摄入有机硒或无机硒的新西兰女性血液成分中的硒分布情况。

Selenium distribution in blood fractions of New Zealand women taking organic or inorganic selenium.

作者信息

Butler J A, Thomson C D, Whanger P D, Robinson M F

机构信息

Department of Agricultural Chemistry, Oregon State University, Corvallis 97331.

出版信息

Am J Clin Nutr. 1991 Mar;53(3):748-54. doi: 10.1093/ajcn/53.3.748.

DOI:10.1093/ajcn/53.3.748

PMID:2000831

Abstract

Three groups of 11 New Zealand women each received, for 32 wk, yeast tablets with no added selenium (placebo) or 200 micrograms Se/d in tablets either as selenate or as selenium-enriched yeast (SeMet) in a double-blind selenium trial. Plasma and erythrocyte (RBC) samples were collected bimonthly. Gel filtration of plasma from women taking SeMet revealed two major selenium-containing peaks with most of the selenium in the second peak. In contrast, the first peak contained most of the selenium in plasma from women taking selenate. Chromatography of RBC lysates indicated that the majority of the selenium was with hemoglobin (Hb) in women taking SeMet but was about equally distributed between glutathione peroxidase (GSH-Px) and Hb in women taking selenate. The percentage of selenium associated with GSH-Px was found to be greater in RBCs and plasma of women taking selenate than of those taking SeMet.

摘要

在一项双盲硒试验中，三组，每组11名新西兰女性，连续32周分别服用不含额外添加硒的酵母片（安慰剂），或每天服用200微克以硒酸盐或富硒酵母（SeMet）形式存在于片剂中的硒。每两个月采集一次血浆和红细胞（RBC）样本。对服用SeMet的女性的血浆进行凝胶过滤，发现有两个主要的含硒峰，大部分硒存在于第二个峰中。相比之下，第一个峰含有服用硒酸盐的女性血浆中的大部分硒。红细胞裂解物的色谱分析表明，服用SeMet的女性中，大部分硒与血红蛋白（Hb）结合，但服用硒酸盐的女性中，硒在谷胱甘肽过氧化物酶（GSH-Px）和Hb之间的分布大致相等。发现服用硒酸盐的女性的红细胞和血浆中与GSH-Px结合的硒的百分比高于服用SeMet的女性。