Subdural fluid collections in patients with infantile neuronal ceroid lipofuscinosis.

OBJECTIVE

To describe subdural fluid collections on magnetic resonance imaging as part of the natural history of infantile neuronal ceroid lipofuscinosis.

DESIGN

Case series.

SETTING

Program on Developmental Endocrinology and Genetics, The Clinical Center, National Institutes of Health, Bethesda, Maryland.

PATIENTS

Patients with infantile neuronal ceroid lipofuscinosis with subdural fluid collections.

MAIN OUTCOME MEASURE

Neurodegeneration on magnetic resonance imaging.

RESULTS

During an ongoing bench-to-bedside clinical investigation, magnetic resonance imaging examinations led to the incidental discovery of subdural fluid collections in 4 of 9 patients with infantile neuronal ceroid lipofuscinosis. No particular event (such as trauma) or change in symptoms was linked to this finding, which was already in the chronic phase when discovered. Of the 4 patients, 1 was followed up for 7 years, 2 for 4 years, and 1 for 2.5 years. Over time, these collections remained stable or decreased in size.

CONCLUSION

Recognition that subdural fluid collections are part of the infantile neuronal ceroid lipofuscinosis disease process may obviate the necessity of additional workup as well as therapeutic interventions in these chronically sick children.