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1
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.
Blood. 2010 Feb 25;115(8):1610-20. doi: 10.1182/blood-2009-07-232249. Epub 2009 Dec 14.
2
Runx1 loss minimally impacts long-term hematopoietic stem cells.
PLoS One. 2011;6(12):e28430. doi: 10.1371/journal.pone.0028430. Epub 2011 Dec 1.
3
Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.
Haematologica. 2019 Nov;104(11):2215-2224. doi: 10.3324/haematol.2018.205351. Epub 2019 Apr 11.
4
A role for RUNX1 in hematopoiesis and myeloid leukemia.
Int J Hematol. 2013 Jun;97(6):726-34. doi: 10.1007/s12185-013-1347-3. Epub 2013 Apr 24.
6
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors.
J Biol Chem. 2016 May 20;291(21):11148-60. doi: 10.1074/jbc.M116.717801. Epub 2016 Apr 4.
7
The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells.
Biochim Biophys Acta Gene Regul Mech. 2017 Jun;1860(6):721-729. doi: 10.1016/j.bbagrm.2017.03.007. Epub 2017 Apr 6.
9
Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis.
Adv Exp Med Biol. 2017;962:139-147. doi: 10.1007/978-981-10-3233-2_10.
10
RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.
Blood. 2009 Jan 22;113(4):883-6. doi: 10.1182/blood-2008-04-153742. Epub 2008 Nov 25.

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1
Inherited Predispositions to Myeloid Neoplasms: Pathogenesis and Clinical Implications.
Annu Rev Pathol. 2025 Jan;20(1):87-114. doi: 10.1146/annurev-pathmechdis-111523-023420. Epub 2025 Jan 2.
2
CK2β Regulates Hematopoietic Stem Cell Biology and Erythropoiesis.
Hemasphere. 2023 Nov 23;7(12):e978. doi: 10.1097/HS9.0000000000000978. eCollection 2023 Dec.
4
The RUNX Family of Proteins, DNA Repair, and Cancer.
Cells. 2023 Apr 7;12(8):1106. doi: 10.3390/cells12081106.
6
Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of -FPD.
Hemasphere. 2023 Jan 31;7(2):e824. doi: 10.1097/HS9.0000000000000824. eCollection 2023 Feb.
7
Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques.
Stem Cell Reports. 2022 Dec 13;17(12):2595-2609. doi: 10.1016/j.stemcr.2022.10.003. Epub 2022 Nov 3.
8
Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective.
Leukemia. 2022 May;36(5):1203-1214. doi: 10.1038/s41375-022-01548-7. Epub 2022 Mar 30.
9
RUNX3 overexpression inhibits normal human erythroid development.
Sci Rep. 2022 Jan 24;12(1):1243. doi: 10.1038/s41598-022-05371-z.
10
Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia.
Leukemia. 2022 Mar;36(3):834-846. doi: 10.1038/s41375-021-01445-5. Epub 2021 Oct 11.

本文引用的文献

1
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder.
Blood. 2009 May 28;113(22):5583-7. doi: 10.1182/blood-2008-07-168260. Epub 2009 Apr 8.
2
AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.
J Immunol. 2008 Apr 1;180(7):4402-8. doi: 10.4049/jimmunol.180.7.4402.
4
Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult.
Stem Cells. 2007 Dec;25(12):2976-86. doi: 10.1634/stemcells.2007-0061. Epub 2007 Sep 6.
6
Targeting of CD44 eradicates human acute myeloid leukemic stem cells.
Nat Med. 2006 Oct;12(10):1167-74. doi: 10.1038/nm1483. Epub 2006 Sep 24.
7
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells.
Nat Med. 2006 Oct;12(10):1175-80. doi: 10.1038/nm1489. Epub 2006 Sep 24.
8
Stem cells and their niches.
Science. 2006 Mar 31;311(5769):1880-5. doi: 10.1126/science.1110542.
9
Bone-marrow haematopoietic-stem-cell niches.
Nat Rev Immunol. 2006 Feb;6(2):93-106. doi: 10.1038/nri1779.

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