Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Cells. 2023 Apr 7;12(8):1106. doi: 10.3390/cells12081106.
The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and solid cancers by impairing DNA repair mechanisms. RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers.
RUNX 家族转录因子，包括 RUNX1、RUNX2 和 RUNX3，是发育的关键调节因子，在癌症中既可以作为肿瘤抑制因子，也可以作为癌基因。新出现的证据表明，RUNX 基因的失调可以通过损害 DNA 修复机制，促进白血病和实体癌中的基因组不稳定性。RUNX 蛋白通过转录或非转录机制调节 p53、范可尼贫血和氧化应激修复途径，控制细胞对 DNA 损伤的反应。本综述强调了 RUNX 依赖性 DNA 修复调节在人类癌症中的重要性。
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