文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

母系西式饮食重塑恒河猴胎儿造血干/祖细胞的转录景观。

Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques.

机构信息

Department of Molecular Biology and Biochemistry, School of Biological Sciences, Institute for Immunology, Center for Virus Research, University of California-Irvine, Irvine, CA 92697, USA.

Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR 97006.

出版信息

Stem Cell Reports. 2022 Dec 13;17(12):2595-2609. doi: 10.1016/j.stemcr.2022.10.003. Epub 2022 Nov 3.

DOI:10.1016/j.stemcr.2022.10.003
PMID:36332628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9768582/
Abstract

Maternal obesity adversely impacts the in utero metabolic environment, but its effect on fetal hematopoiesis remains incompletely understood. During late development, the fetal bone marrow (FBM) becomes the major site where macrophages and B lymphocytes are produced via differentiation of hematopoietic stem and progenitor cells (HSPCs). Here, we analyzed the transcriptional landscape of FBM HSPCs at single-cell resolution in fetal macaques exposed to a maternal high-fat Western-style diet (WSD) or a low-fat control diet. We demonstrate that maternal WSD induces a proinflammatory response in FBM HSPCs and fetal macrophages. In addition, maternal WSD consumption suppresses the expression of B cell development genes and decreases the frequency of FBM B cells. Finally, maternal WSD leads to poor engraftment of fetal HSPCs in nonlethally irradiated immunodeficient NOD/SCID/IL2rγ mice. Collectively, these data demonstrate for the first time that maternal WSD impairs fetal HSPC differentiation and function in a translationally relevant nonhuman primate model.

摘要

母体肥胖会对宫内代谢环境产生不利影响，但它对胎儿造血的影响仍不完全清楚。在晚期发育过程中，胎儿骨髓（FBM）成为通过造血干细胞和祖细胞（HSPCs）分化产生巨噬细胞和 B 淋巴细胞的主要部位。在这里，我们在暴露于母体高脂肪西式饮食（WSD）或低脂对照饮食的胎儿猕猴中，以单细胞分辨率分析了 FBM HSPCs 的转录组景观。我们证明母体 WSD 会在 FBM HSPCs 和胎儿巨噬细胞中引发炎症反应。此外，母体 WSD 摄入会抑制 B 细胞发育基因的表达并降低 FBM B 细胞的频率。最后，母体 WSD 导致胎儿 HSPC 在非致死性辐照免疫缺陷 NOD/SCID/IL2rγ 小鼠中的植入不良。总的来说，这些数据首次表明母体 WSD 会损害转化相关非人类灵长类动物模型中胎儿 HSPC 的分化和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/72dbb0b5a7c1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/6c0e2b8d21fc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/d10b67e7d6a3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/ecc2a808212d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/01bf3eb32f06/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/78d6ed5603d3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/72dbb0b5a7c1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/6c0e2b8d21fc/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/d10b67e7d6a3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/ecc2a808212d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/01bf3eb32f06/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/78d6ed5603d3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafa/9768582/72dbb0b5a7c1/gr5.jpg

相似文献

[1]
Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques.

Stem Cell Reports. 2022-12-13

[2]
Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity.

Front Hematol. 2025

[3]
Fetal liver CD34 contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice.

Stem Cell Res Ther. 2024-6-9

[4]
Glucose intolerance as a consequence of hematopoietic stem cell dysfunction in offspring of obese mice.

Mol Metab. 2024-10

[5]
Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques.

Sci Rep. 2025-7-1

[6]
Maternal Western Diet Programmes Bile Acid Dysregulation and Hepatic Fibrosis in Fetal and Juvenile Macaques.

Liver Int. 2025-2

[7]
Development of VLA4 and CXCR4 Antagonists for the Mobilization of Hematopoietic Stem and Progenitor Cells.

Biomolecules. 2024-8-14

[8]
Silencing endomucin in bone marrow sinusoids improves hematopoietic stem and progenitor cell homing during transplantation.

Stem Cells. 2024-10-9

[9]
Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development.

Geroscience. 2025-4-15

[10]
Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.

Am J Physiol Endocrinol Metab. 2022-9-1

引用本文的文献

[1]
Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity.

Front Hematol. 2025

[2]
Kupffer cell programming by maternal obesity triggers fatty liver disease.

Nature. 2025-6-18

[3]
High-Fat Diet and Altered Radiation Response.

Biology (Basel). 2025-3-22

[4]
Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective.

Nutr J. 2025-1-23

[5]
Developmental programming of tissue-resident macrophages.

Front Immunol. 2024

[6]
Glucose intolerance as a consequence of hematopoietic stem cell dysfunction in offspring of obese mice.

Mol Metab. 2024-10

[7]
Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring.

Int J Mol Sci. 2024-5-29

[8]
Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity.

Nutrients. 2024-5-3

[9]
A review of single-cell transcriptomics and epigenomics studies in maternal and child health.

Epigenomics. 2024

[10]
Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques.

Am J Reprod Immunol. 2023-10

本文引用的文献

[1]
Translational Utility of the Nonhuman Primate Model.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2022-5

[2]
Niches that regulate stem cells and hematopoiesis in adult bone marrow.

Dev Cell. 2021-7-12

[3]
Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn.

Front Immunol. 2021

[4]
Placental Glucose Uptake in a Nonhuman Primate Model of Western-Style Diet Consumption and Chronic Hyperandrogenemia Exposure.

Reprod Sci. 2021-9

[5]
Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD.

J Cell Immunol. 2020

[6]
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis.

Cell Stem Cell. 2021-3-4

[7]
Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques.

Hum Reprod. 2021-1-25

[8]
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.

Cell Stem Cell. 2020-11-5

[9]
Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates.

Blood. 2021-1-14

[10]
An Erg-driven transcriptional program controls B cell lymphopoiesis.

Nat Commun. 2020-6-15

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索