Shin Ji-Yeon, Hwang Jun-Hyun, Jeong Jin-Young, Kim Sung-Hi, Moon Jai-Dong, Roh Sang-Chul, Kim Young-Wook, Kim Yangho, Leem Jong-Han, Ju Young-Su, Hong Young-Seoub, Ha Eun-Hee, Lee Yong-Hwan, Lee Duk-Hee, Kim Dong-Hyun
Department of Preventive Medicine, Kyungpook National University School of Medicine, Korea.
J Prev Med Public Health. 2009 Nov;42(6):386-91. doi: 10.3961/jpmph.2009.42.6.386.
This cross-sectional study was performed to examine if the serum gamma-glutamyltransferase (GGT) level that is within its normal range is associated with the risk of type 2 diabetes and if the association between the waist hip ratio (WHR) and type 2 diabetes is different depending on the serum GGT levels.
The study subjects were 23,436 persons aged 40 years or older and who participated in regular health check-ups at 11 hospitals (males: 5,821, females: 17,615). The gender-specific quintiles of the serum GGT and WHR were used to examine the associations with type 2 diabetes.
The serum GGT levels within their normal range were positively associated with type 2 diabetes only in women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4, 2.1, and 2.5 according to the quintiles of the serum GGT (p(trend)<0.01). The WHR was more strongly associated with the prevalence of diabetes among the women with a high-normal serum GGT level as compared with those with a low-normal serum GGT level (p for interaction=0.02). For example, the adjusted ORs for women with a low normal serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according to the quintiles of the WHR, while those figures were 1.0, 2.4, 3.6, 5.0, and 8.3 among the women with a high normal serum GGT level. However, in men, the serum GGT was very weakly associated with type 2 diabetes and the association between the WHR and type 2 diabetes was not different depending on the serum GGT level.
Serum GGT within its normal range was positively associated with type 2 diabetes, and central obesity was more strongly associated with the prevalence of type 2 diabetes when the serum GGT level was high-normal. However, these associations were observed only in women, which is different from the previous findings. The stronger relation between central obesity and type 2 diabetes among women with a high-normal serum GGT level can be useful for selecting a group that is at high risk for type 2 diabetes irregardless of whatever the underlying mechanism is.
本横断面研究旨在检验正常范围内的血清γ-谷氨酰转移酶（GGT）水平是否与2型糖尿病风险相关，以及腰臀比（WHR）与2型糖尿病之间的关联是否因血清GGT水平而异。
研究对象为23436名40岁及以上且在11家医院参加定期健康检查的人（男性：5821名，女性：17615名）。采用血清GGT和WHR的性别特异性五分位数来检验与2型糖尿病的关联。
仅在女性中，正常范围内的血清GGT水平与2型糖尿病呈正相关。根据血清GGT的五分位数，调整后的比值比（OR）分别为1.0、1.0、1.4、2.1和2.5（趋势p<0.01）。与血清GGT水平正常偏低的女性相比，血清GGT水平正常偏高的女性中，WHR与糖尿病患病率的关联更强（交互作用p=0.02）。例如，血清GGT水平正常偏低的女性，根据WHR的五分位数，调整后的OR分别为1.0、1.2、1.5、2.2和2.4，而血清GGT水平正常偏高的女性中，这些数字分别为1.0、2.4、3.6、5.0和8.3。然而，在男性中，血清GGT与2型糖尿病的关联非常弱，且WHR与2型糖尿病之间的关联不因血清GGT水平而异。
正常范围内的血清GGT与2型糖尿病呈正相关，当血清GGT水平正常偏高时，中心性肥胖与2型糖尿病患病率的关联更强。然而，这些关联仅在女性中观察到，这与之前的研究结果不同。血清GGT水平正常偏高的女性中，中心性肥胖与2型糖尿病之间更强的关联，无论其潜在机制如何，都有助于选择2型糖尿病高危人群。
