Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
RNA Biol. 2010 Jan-Feb;7(1):5-12. doi: 10.4161/rna.7.1.10256. Epub 2010 Jan 6.
Regulation of gene expression at the post-transcriptional level such as control of mRNA translation and stability is of fundamental importance because it allows cells to respond quickly to external signals, and change protein synthesis without new transcriptional activity. As such, control of translation and stability of mRNA play crucial roles in a variety of cellular processes, including regulating normal cellular growth, embryogenesis and neuronal plasticity. Consequently, misregulation of mRNA translation or degradation can be associated with a number of human diseases, such as cancer and diabetes. Studies have shown that the cytoplasmic poly (A)-binding protein (PABP) plays a crucial role in regulating both translation and stability of eukaryotic mRNA.
在转录后水平上调节基因表达，如控制 mRNA 的翻译和稳定性，是至关重要的，因为它使细胞能够快速对外界信号做出反应，并在没有新的转录活性的情况下改变蛋白质合成。因此，mRNA 的翻译和稳定性控制在多种细胞过程中起着至关重要的作用，包括调节正常细胞生长、胚胎发生和神经元可塑性。因此，mRNA 翻译或降解的失调可能与许多人类疾病有关，如癌症和糖尿病。研究表明，细胞质多聚（A）结合蛋白（PABP）在调节真核 mRNA 的翻译和稳定性方面起着关键作用。
