Department of Gynecology Oncology, University Hospital of Canary Islands, Las Palmas de Gran Canaria, Spain.
Int J Gynecol Cancer. 2009 Nov;19(8):1364-9. doi: 10.1111/IGC.0b013e3181b7a1d5.
The aim of this study was to evaluate the clinicopathological data and prognosis factors corresponding to patients with papillary serous carcinoma of the endometrium treated at a single institution.
Medical and anatomopathological records were reviewed in the Department of Gynecological Oncology of the Canarian University Hospital between 1989 and 2006. Only pure cases of papillary serous carcinoma of the endometrium were included. Survival rates were analyzed using the Kaplan-Meier technique.
The study included 61 patients. Stages I, II, III, and IV were identified in 32.8%, 19.7%, 31.1%, and 8.2% of patients, respectively. Event-free survival rates after 5 and 10 years were 59% and 40%, respectively, with a median time of 83 months (95% confidence interval, 63-110). Relapse occurred in 40.5% of the patients. Overall survival rates after 5 and 10 years were 37.7% and 29%, respectively, with a median time of 55 months (95% confidence interval, 40-70). A univariate analysis showed that prognosis factors were tumor markers, stage, myometrial infiltration, lymphovascular invasion, and ganglia involvement. A multivariate analysis showed that tumor markers, stage, and myometrial infiltration had an independent influence on overall survival.
Papillary serous carcinoma of the endometrium is a very aggressive type of endometrial carcinoma that behaves more similar to ovarian carcinoma than to endometrial carcinoma. Tumor markers at diagnosis, stage, and myometrial infiltration mainly determine prognosis at our institution.
本研究旨在评估单一机构治疗的子宫内膜乳头状浆液性癌患者的临床病理数据和预后因素。
回顾 1989 年至 2006 年在加那利群岛大学医院妇科肿瘤科的医疗和解剖病理记录。仅包括纯子宫内膜乳头状浆液性癌病例。使用 Kaplan-Meier 技术分析生存率。
本研究纳入 61 例患者。Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期患者分别占 32.8%、19.7%、31.1%和 8.2%。5 年和 10 年无事件生存率分别为 59%和 40%，中位时间分别为 83 个月（95%置信区间，63-110）。40.5%的患者复发。5 年和 10 年总生存率分别为 37.7%和 29%，中位时间分别为 55 个月（95%置信区间，40-70）。单因素分析显示，预后因素包括肿瘤标志物、分期、肌层浸润、淋巴血管浸润和神经节浸润。多因素分析显示，肿瘤标志物、分期和肌层浸润对总生存有独立影响。
子宫内膜乳头状浆液性癌是一种侵袭性很强的子宫内膜癌，其行为更类似于卵巢癌，而不是子宫内膜癌。本机构的诊断肿瘤标志物、分期和肌层浸润主要决定预后。
