Department of Radiation Oncology, Thomas Jefferson University, St Louis, MO, USA.
Int J Gynecol Cancer. 2009 Nov;19(8):1412-4. doi: 10.1111/IGC.0b013e3181b62e8c.
Cervical cancer tumor size determined by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) thresholding of the maximum standardized uptake value (SUVMax) has been correlated with the determined tumor size by computed tomography and magnetic resonance imaging. The purpose of this study was to evaluate the relationship between preoperative FDG-PET tumor size and pathologic tumor diameter in patients with early-stage cervical cancer who were undergoing radical hysterectomy.
Forty patients with early-stage cervical cancer underwent pretreatment FDG-PET/computed tomography before radical hysterectomy and lymph node dissection. Primary tumor diameter was defined on FDG-PET as the largest diameter of the 3-dimensional volumetric isocontour of the 40% threshold of the SUVMax. The FDG-PET measurements were compared with the tumor diameter and the histological diameter of the pathologic specimen using regression analysis, paired t test, and unpaired t test.
The FDG-PET tumor diameter measurements were correlated to the pathologic tumor diameter in the surgical specimen with a coefficient of determination (R2) of 0.951 and a correlation coefficient of 0.757 (P < 0.0001).
There is a high level of correlation in the FDG-PET and the pathologic tumor measurements in the early-stage cervical cancer.
通过正电子发射断层扫描（FDG-PET）最大标准化摄取值（SUVMax）的阈值对宫颈癌肿瘤大小进行测定，与计算机断层扫描和磁共振成像确定的肿瘤大小相关。本研究旨在评估在接受根治性子宫切除术的早期宫颈癌患者中，术前 FDG-PET 肿瘤大小与病理肿瘤直径之间的关系。
40 例早期宫颈癌患者在根治性子宫切除术和淋巴结清扫术前进行 FDG-PET/计算机断层扫描。FDG-PET 上的原发性肿瘤直径定义为 SUVMax 的 40%阈值的三维容积等容线的最大直径。使用回归分析、配对 t 检验和独立 t 检验比较 FDG-PET 测量值与肿瘤直径和病理标本的组织学直径。
FDG-PET 肿瘤直径测量值与手术标本中的病理肿瘤直径具有高度相关性，决定系数（R2）为 0.951，相关系数为 0.757（P<0.0001）。
早期宫颈癌的 FDG-PET 和病理肿瘤测量值具有高度相关性。
