Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland.
Cancer Nurs. 2010 Jan-Feb;33(1):E1-E10. doi: 10.1097/NCC.0b013e3181b4adb5.
The overall survival gain of cancer chemotherapy is estimated to be small, and some claim that it rarely improves quality of life (QOL). The purpose of this population-based study was to describe QOL and symptoms of anxiety and depression, over time, in a group of Icelandic cancer patients receiving chemotherapy. Quality of life was measured with the Icelandic version of Cancer Rehabilitation Evaluation System, Short Form (CARES-SF), and symptoms of anxiety and depression, with the Icelandic version of Hospital Anxiety and Depression Scale (HADS). Enrolled into the study were 144 patients, 90 women and 54 men; mean (SD) age was 55 (12.1) years. Although QOL was found relatively good during the period of chemotherapy, it was significantly worse after 3 and 6 months compared to baseline. Quality of life was found worst in the sexual and physical domains. At all time points, a significant association was found between symptoms of anxiety and depression and QOL with those reporting symptoms of either anxiety or depression experiencing worse QOL. The good QOL found during the period of chemotherapy is a positive finding. The results, however, call for an intense assessment, over time, of physical symptoms, anxiety, and depression, as well as sexuality issues.
癌症化疗的总体生存获益估计较小，有人声称它很少能提高生活质量（QOL）。本基于人群的研究旨在描述一组接受化疗的冰岛癌症患者随时间推移的 QOL 以及焦虑和抑郁症状。QOL 用冰岛版癌症康复评估系统简表（CARES-SF）测量，焦虑和抑郁症状用冰岛版医院焦虑和抑郁量表（HADS）测量。该研究纳入了 144 名患者，90 名女性和 54 名男性；平均（SD）年龄为 55（12.1）岁。尽管在化疗期间发现 QOL 相对较好，但与基线相比，在 3 个月和 6 个月后明显更差。在所有时间点，焦虑和抑郁症状与 QOL 之间均存在显著关联，报告有焦虑或抑郁症状的患者 QOL 更差。在化疗期间发现的良好 QOL 是一个积极的发现。然而，结果需要随着时间的推移，对身体症状、焦虑和抑郁以及性功能问题进行密集评估。
