鳞状小汗腺导管癌：一例报告并文献复习

Squamoid eccrine ductal carcinoma: a case report and review of the literature.

作者信息

Terushkin Elina, Leffell David J, Futoryan Tanya, Cowper Shawn, Lazova Rossitza

机构信息

From the *Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA; †Department of Dermatology, Yale University School of Medicine, New Haven, CT; and ‡Westport Dermatology, Westport, CT.

出版信息

Am J Dermatopathol. 2010 May;32(3):287-292. doi: 10.1097/DAD.0b013e3181b623c4.

DOI:10.1097/DAD.0b013e3181b623c4

PMID:20010402

Abstract

Eccrine ductal carcinoma is a rare adnexal tumor. Squamoid eccrine ductal carcinoma (SEDC) represents an exceptionally rare variant with only 6 cases reported to date. This neoplasm is deeply infiltrative and may provide a diagnostic challenge in superficial shave biopsies of skin. We present a case of SEDC in an immunocompromised patient, who, after an initial shave biopsy for diagnostic purposes, underwent a complete excision of his tumor by Mohs micrographic surgery. A combined histologic and immunohistochemical approach is necessary to identify and confirm the unique characteristics of SEDC. Because this cancer is very rare and little is known about its biologic behavior, optimal diagnostic and treatment guidelines need to be developed.

摘要

小汗腺导管癌是一种罕见的附属器肿瘤。鳞状小汗腺导管癌（SEDC）是一种极其罕见的变异型，迄今为止仅有6例报道。这种肿瘤具有深部浸润性，在皮肤浅表削除活检中可能带来诊断挑战。我们报告一例免疫功能低下患者的SEDC病例，该患者最初为诊断目的进行了削除活检，之后通过莫氏显微外科手术对肿瘤进行了完整切除。需要采用组织学和免疫组化相结合的方法来识别和确认SEDC的独特特征。由于这种癌症非常罕见，对其生物学行为了解甚少，因此需要制定最佳的诊断和治疗指南。