McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Mol Psychiatry. 2011 Feb;16(2):216-26. doi: 10.1038/mp.2009.132. Epub 2009 Dec 15.
Suicide completion rates are significantly higher in males than females in most societies. Although gender differences in suicide rates have been partially explained by environmental and behavioral factors, it is possible that genetic factors, through differential expression between genders, may also help explain gender moderation of suicide risk. This study investigated X-linked genes in suicide completers using a two-step strategy. We first took advantage of the genetic structure of the French-Canadian population and genotyped 722 unrelated French-Canadian male subjects, of whom 333 were suicide completers and 389 were non-suicide controls, using a panel of 37 microsatellite markers spanning the entire X chromosome. Nine haplotype windows and several individual markers were associated with suicide. Significant results aggregated primarily in two regions, one in the long arm and another in the short arm of chromosome X, limited by markers DXS8051 and DXS8102, and DXS1001 and DXS8106, respectively. The second stage of the study investigated differential brain expression of genes mapping to associated regions in Brodmann areas 8/9, 11, 44 and 46, in an independent sample of suicide completers and controls. Six genes within these regions, Rho GTPase-activating protein 6, adaptor-related protein complex 1 sigma 2 subunit, glycoprotein M6B, ribosomal protein S6 kinase 90 kDa polypeptide 3, spermidine/spermine N(1)-acetyltransferase 1 and THO complex 2, were found to be differentially expressed in suicide completers.
在大多数社会中，男性自杀完成率明显高于女性。尽管自杀率的性别差异部分可以通过环境和行为因素来解释，但遗传因素可能通过性别间的差异表达，也有助于解释自杀风险的性别调节。本研究采用两步策略研究了自杀者的 X 连锁基因。我们首先利用法裔加拿大人群的遗传结构，对 722 名无亲缘关系的法裔加拿大男性进行基因分型，其中 333 名是自杀完成者，389 名是非自杀对照者，使用了一个跨越整个 X 染色体的 37 个微卫星标记的面板。9 个单体型窗口和几个个体标记与自杀有关。主要聚集在两个区域的显著结果，一个在 X 染色体的长臂，另一个在短臂，分别由标记 DXS8051 和 DXS8102、DXS1001 和 DXS8106 限制。研究的第二阶段调查了与布罗德曼区 8/9、11、44 和 46 相关区域映射的基因在独立的自杀者和对照组中的大脑差异表达。在这些区域内的六个基因，Rho GTPase-activating protein 6、adapter-related protein complex 1 sigma 2 subunit、glycoprotein M6B、ribosomal protein S6 kinase 90 kDa polypeptide 3、spermidine/spermine N(1)-acetyltransferase 1 和 THO complex 2，在自杀者中发现有差异表达。
