细胞外钙对新生大鼠内嗅皮层神经元群峰活动的影响：计算机模拟
Effects of extracellular calcium on the volley activity of entorhinal cortex neurons in neonatal rats: computer simulation.
作者信息
Sheroziya M G, Egorov A V
机构信息
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
出版信息
Neurosci Behav Physiol. 2010 Jan;40(1):1-4. doi: 10.1007/s11055-009-9229-0. Epub 2009 Dec 11.
PMID:20012490
Abstract
The calcium-dependent volley activity of neurons in the entorhinal cortex of neonatal rats increased when the extracellular Ca(2+) concentration decreased from 2 to 1 mM. This may be associated with changes in the properties of the slow sodium current. Computer simulation of volley neurons using a model including a relationship between the slow sodium current and extracellular Ca(2+) supported this suggestion.
摘要
新生大鼠内嗅皮质神经元的钙依赖性群峰活动在细胞外Ca(2+)浓度从2 mM降至1 mM时增加。这可能与慢钠电流特性的变化有关。使用包含慢钠电流与细胞外Ca(2+)之间关系的模型对群峰神经元进行计算机模拟支持了这一观点。
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