Huzot Clinic, Clalit Health Services, Ashkelon, Israel.
Mycopathologia. 2010 May;169(5):343-9. doi: 10.1007/s11046-009-9265-x. Epub 2009 Dec 13.
Onychomycosis is a common disease. Topical treatment is usually not effective due to limitation of trans-nail delivery of antifungal drugs. Successful treatment of deep-seated nail infections remains elusive as the delivery of efficacious levels of antifungal drug to the site of action is very difficult.
To evaluate the influence of several parameters including; the effect of low electrical current, incubation time and the presence of electrolyte (NaCl or KCl) on the penetration of terbinafine through the nail plate into the nail bed, using various formulations and concentrations of terbinafine HCl.
Iontophoresis was applied across porcine and human nail in vitro to assess its efficiency in enhancing delivery of terbinafine HCl.
In this study, we have demonstrated that an optimal electrolyte concentration (1% NaCl or KCl) is required for an effective delivery. There is a significant increase in drug delivery into the nail and into the receiving compartment in the presence of 3% DMSO.
This study demonstrates the efficacy of iontophoresis in enhancing the trans-nail delivery of terbinafine. Clinical studies are needed to evaluate the feasibility, efficacy and safety of iontophoresis of terbinafine in onychomycosis in human.
甲真菌病是一种常见疾病。由于抗真菌药物向指甲内传递的局限性，局部治疗通常效果不佳。由于很难将有效的抗真菌药物递送至作用部位，深部指甲感染的成功治疗仍然难以实现。
评估多种参数的影响，包括：低电流的影响、孵育时间以及电解质（NaCl 或 KCl）的存在对特比萘芬通过指甲板渗透到甲床的影响，使用不同浓度和配方的盐酸特比萘芬。
将离子电渗疗法应用于体外猪和人指甲，以评估其增强盐酸特比萘芬递送的效率。
在这项研究中，我们已经证明，有效的传递需要最佳的电解质浓度（1%NaCl 或 KCl）。在存在 3%DMSO 的情况下，药物向指甲和接收隔室的递送显著增加。
这项研究证明了离子电渗疗法在增强特比萘芬向指甲内传递方面的有效性。需要进行临床研究，以评估离子电渗疗法在人类甲真菌病中的可行性、疗效和安全性。
