Rehabilitation Research and Development Center of Excellence for the Medical Consequences of Spinal Cord Injury, The James J. Peters VA Medical Center, Rm. 1E-02, 130 West Kingsbridge Road, Bronx, NY 10468, USA.
Lung. 2010 Jun;188(3):259-62. doi: 10.1007/s00408-009-9207-x. Epub 2009 Dec 15.
The role of airway inflammation in mediating airflow obstruction in persons with chronic traumatic tetraplegia is unknown. Measurement of the fraction of exhaled nitric oxide (FeNO) affords a validated noninvasive technique for gauging the airway inflammatory response in asthma, although it has never been assessed in persons with tetraplegia. This study was designed to determine the FeNO in individuals with chronic tetraplegia compared with that in patients with mild asthma and healthy able-bodied individuals. Nine subjects with chronic tetraplegia, seven subjects with mild asthma, and seven matched healthy able-bodied controls were included in this prospective, observational, pilot study. All subjects were nonsmokers and clinically stable at the time of study. Spirometry was performed on all participants at baseline. FENO was determined online by a commercially available closed circuit, chemiluminescence method, using a single-breath technique. Subjects with tetraplegia had significantly higher values of FeNO than controls (17.72 +/- 3.9 ppb vs. 10.37 +/- 4.9 ppb; P < or = 0.01), as did subjects with asthma (20.23 +/- 4.64 ppb vs. 10.37 +/- 4.9 ppb, P < or = 0.001). There was no significant difference in FeNO between subjects with tetraplegia and those with asthma (17.72 +/- 3.9 ppb vs. 20.23 +/- 4.64 ppb, P < or = 0.27). Individuals with chronic tetraplegia have FeNO levels that are comparable to that seen in mild asthmatics and higher than that in healthy able-bodied controls. The clinical relevance of this observation has yet to be determined.
气道炎症在介导慢性创伤性四肢瘫痪患者气流阻塞中的作用尚不清楚。呼出气一氧化氮（FeNO）的测量提供了一种验证的非侵入性技术，用于衡量哮喘中的气道炎症反应，尽管它从未在四肢瘫痪患者中进行过评估。本研究旨在确定慢性四肢瘫痪患者的 FeNO 与轻度哮喘患者和健康的非残疾个体的 FeNO 相比。这项前瞻性观察性初步研究纳入了 9 名慢性四肢瘫痪患者、7 名轻度哮喘患者和 7 名匹配的健康非残疾对照者。所有受试者均为不吸烟者，在研究时临床稳定。所有参与者均进行了基础肺量计检查。通过商业上可获得的闭合回路化学发光法，使用单次呼吸技术在线测定 FENO。四肢瘫痪患者的 FeNO 值明显高于对照组（17.72±3.9 ppb 比 10.37±4.9 ppb；P≤0.01），哮喘患者也高于对照组（20.23±4.64 ppb 比 10.37±4.9 ppb，P≤0.001）。四肢瘫痪患者与哮喘患者的 FeNO 值无显著差异（17.72±3.9 ppb 比 20.23±4.64 ppb，P≤0.27）。慢性四肢瘫痪患者的 FeNO 水平与轻度哮喘患者相似，高于健康非残疾对照者。这种观察的临床意义尚未确定。
