UCD Institute of Food & Health, UCD Agriculture & Food Science Centre, University College Dublin, Belfield, Dublin 4, Ireland.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Apr;27(4):447-56. doi: 10.1080/19440040903470718.
A double-blind randomized intervention study has previously shown that a significant relationship exists between the consumption of various mixes of seven target additives by children and the onset of hyperactive behaviour. The present study set out to ascertain the pattern of intake of two mixes (A and B) of these seven target additives in Irish children and teenagers using the Irish national food consumption databases for children (n = 594) and teenagers (n = 441) and the National Food Ingredient Database. The majority of additive-containing foods consumed by both the children and teenagers contained one of the target additives. No food consumed by either the children or teenagers contained all seven of the target food additives. For each additive intake, estimates for every individual were made assuming that the additive was present at the maximum legal permitted level in those foods identified as containing it. For both groups, mean intakes of the food additives among consumers only were far below the doses used in the previous study on hyperactivity. Intakes at the 97.5th percentile of all food colours fell below the doses used in Mix B, while intakes for four of the six food colours were also below the doses used in Mix A. However, in the case of the preservative sodium benzoate, it exceeded the previously used dose in both children and teenagers. No child or teenager achieved the overall intakes used in the study linking food additives with hyperactivity.
一项双盲随机干预研究此前表明,儿童摄入七种目标添加剂的各种混合物与多动行为的发生之间存在显著关系。本研究旨在使用爱尔兰儿童(n=594)和青少年(n=441)的国家食物消费数据库以及国家食物成分数据库,确定爱尔兰儿童和青少年摄入两种混合添加剂(A 和 B)的模式。儿童和青少年所消费的大多数含添加剂食品都含有一种目标添加剂。儿童或青少年所消费的任何食物都不含有所有七种目标食品添加剂。对于每种添加剂的摄入量,对于每一个人都进行了估计,假设在确定含有该添加剂的食物中,添加剂的含量达到了法定的最高允许水平。对于这两个群体,仅消费者的食品添加剂平均摄入量远低于之前关于多动性研究中使用的剂量。所有食用色素的摄入量中值都低于 B 混合物中使用的剂量,而六种食用色素中的四种摄入量也低于 A 混合物中使用的剂量。然而,就防腐剂苯甲酸钠而言,它在儿童和青少年中都超过了之前使用的剂量。没有儿童或青少年达到与食物添加剂与多动性相关的研究中使用的总体摄入量。