Medical University of Innsbruck, Innsbruck Medical University, Innsbruck, Austria.
J Reconstr Microsurg. 2010 Feb;26(2):117-21. doi: 10.1055/s-0029-1243296. Epub 2009 Dec 10.
The dose-dependent effect of extracorporeal shock wave technology (ESWT) was evaluated using a murine skin flap model. Thirty-six Sprague-Dawley rats were divided into six groups (ESWT groups 1 through 5 and a control group). After surgery, shock wave impulses doses were administered: 200 (group 1), 500 (group 2), 1500 (group 3), 2500 (group 4), 5000 (group 5), and 0 (control group 6). Flap viability was evaluated on day 7. Overall, significantly smaller percentages of necrotic zones were observed in groups 2, 3, and 4 compared with groups 1, 5, and the control group ( P < 0.05). ESWT treatment with 200 impulses was found to be ineffective. ESWT treatment of 5000 impulses resulted in a significant increase in the percentage of necrosis compared with other ESWT groups ( P < 0.05). However, ESWT treatments between 500 and 2500 impulses at 0.11 mJ/mm (2) enhanced epigastric skin flap survival significantly.
采用鼠皮瓣模型评价体外冲击波技术（ESWT）的剂量依赖性效应。将 36 只 Sprague-Dawley 大鼠分为六组（ESWT 组 1 至 5 组和对照组）。手术后给予冲击波脉冲剂量：200（组 1）、500（组 2）、1500（组 3）、2500（组 4）、5000（组 5）和 0（对照组 6）。第 7 天评估皮瓣存活率。总体而言，与组 1、组 5 和对照组相比，组 2、组 3 和组 4 的坏死区域百分比明显更小（P <0.05）。发现 200 次冲击的 ESWT 治疗无效。与其他 ESWT 组相比，5000 次冲击的 ESWT 治疗导致坏死百分比显著增加（P <0.05）。然而，0.11 mJ/mm（2）处 500 至 2500 次冲击的 ESWT 治疗显著提高了腹侧皮瓣的存活率。
