Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China.
Chemistry. 2010 Jan 25;16(4):1168-74. doi: 10.1002/chem.200902627.
A supramolecular hybrid is prepared by the supramolecular surface modification of single-walled carbon nanotube (SWCNT) with cationic beta-cyclodextrin-tethered ruthenium complexes through a spacer molecule that contains both an adamantane and a pyrene moiety. By employing the supramolecular hybrid, spatially controllable DNA condensation along the SWCNT skeleton is achieved by anchoring cationic ruthenium complexes on the surface. Furthermore, because of the unique physiological properties of SWCNTs, the cationic supramolecular hybrid can be used as a nonviral gene delivery system with the ruthenium complexes as a fluorescent probe to monitor uptake of DNA by cells.
通过在含有金刚烷和苝部分的间隔分子上将阳离子型 β-环糊精键合钌配合物进行超分子表面修饰，制备了一种超分子杂化体。通过使用超分子杂化体，通过将阳离子型钌配合物固定在表面上，实现了沿 SWCNT 骨架的空间可控 DNA 凝聚。此外，由于 SWCNTs 的独特生理特性，该阳离子超分子杂化物可用作非病毒基因传递系统，其中钌配合物可用作荧光探针来监测细胞对 DNA 的摄取。
