Gullino P M
Am J Pathol. 1977 Nov;89(2):413-30.
The general characteristics of the preneoplastic lesions of the human mammary gland, as they are known through histologic description, are outlined, and data obtained from the experimental analysis of mammary gland preneoplasia in five areas of endeavor are discussed. Results obtained with transplantation procedures and aimed at defining the growth potential of hyperplastic outgrowths are reported. Information derived from the study of events able to induce benign hyperplastic outgrowths or their malignant transformation in the murine mammary gland is summarized. Attempts to predict neoplastic transformation in morphologically hyperplastic epithelium of human and rodent glands are discussed. The present status of efforts toward the prophylaxis of preneoplastic lesions of the mammary gland is described. Considerations of the relationship between preneoplasia and tumor dormancy conclude the presentation.
概述了通过组织学描述所知的人类乳腺肿瘤前病变的一般特征，并讨论了从五个研究领域对乳腺肿瘤前病变进行实验分析所获得的数据。报告了通过移植程序获得的旨在确定增生性赘生物生长潜力的结果。总结了从对能够诱导小鼠乳腺良性增生性赘生物或其恶性转化的事件的研究中获得的信息。讨论了预测人类和啮齿动物腺体形态学增生上皮肿瘤转化的尝试。描述了预防乳腺肿瘤前病变的努力现状。对肿瘤前病变与肿瘤休眠之间关系的思考作为报告的结尾。
