Sinha D, Dao T L
Cancer Lett. 1977 Jan;2(3):153-60. doi: 10.1016/s0304-3835(77)80005-0.
Carcinogen-induced hyperplastic alveolar nodules failed to form tumors after transplantation into isologous female rats; instead they developed ductal or ductal-alveolar outgrowths. Mammary glands from mid-pregnant female rats showed similar outgrowths following transplantation to the isologous hosts. In vitro and in vivo studies failed to demonstrate that subcarcinogenic doses of 7,12-dimethylbenz(a)anthracene can induce mammary tumorigenesis in the hyperplastic alveolar nodules. Our observations suggest that carcinogen-induced hyperplastic alveolar nodules are not 'preneoplastic' lesions in mammary carcinogenesis in the rat.
致癌物诱导的增生性肺泡结节移植到同基因雌性大鼠体内后未能形成肿瘤；相反，它们发展为导管或导管-肺泡增生。妊娠中期雌性大鼠的乳腺移植到同基因宿主后也出现了类似的增生。体外和体内研究均未能证明亚致癌剂量的7,12-二甲基苯并(a)蒽能在增生性肺泡结节中诱导乳腺肿瘤发生。我们的观察结果表明，致癌物诱导的增生性肺泡结节在大鼠乳腺致癌过程中不是“癌前”病变。
