Lundberg J M, Franco-Cereceda A, Lacroix J S, Pernow J
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Blood Vessels. 1991;28(1-3):27-34. doi: 10.1159/000158840.
Release of specific vasoactive peptides occurs upon activation of perivascular parasympathetic (vasoactive intestinal polypeptide and peptide histidine isoleucine), sympathetic (neuropeptide Y) and sensory (calcitonin gene-related peptide and tachykinins) nerves. These peptides may serve as cotransmitters with acetylcholine and noradrenaline with interactions both at the pre- and postjunctional levels. Some long-lasting nonadrenergic, noncholinergic vascular effects upon nerve activation may thus be peptide-mediated. Strong activation seems to be necessary for peptidergic transmission in the parasympathetic and sympathetic system while local sensory mechanisms may occur even at single impulses.
特定血管活性肽在血管周围副交感神经(血管活性肠肽和组氨酸异亮氨酸肽)、交感神经(神经肽Y)和感觉神经(降钙素基因相关肽和速激肽)激活时释放。这些肽可能作为乙酰胆碱和去甲肾上腺素的共递质,在节前和节后水平均有相互作用。因此,神经激活后一些持久的非肾上腺素能、非胆碱能血管效应可能由肽介导。在副交感神经系统和交感神经系统中,肽能传递似乎需要强烈激活,而局部感觉机制甚至在单个冲动时也可能发生。