Weaver L C
Am J Physiol. 1977 Nov;233(5):H592-9. doi: 10.1152/ajpheart.1977.233.5.H592.
Cardiopulmonary sympathetic afferent nerves may affect renal control of intravascular volume by influencing renal sympathetic nerve activity. This influence was evaluated in alpha-chloralose anesthetized, vagotomized, sino-aortic denervated cats. When the afferent nerves were activated with a single electrical stimulus, the renal nerve responded with an excitatory burst of activity followed by a long period of inhibition. This response had characteristics of a supraspinal reflex. Repetitive stimulation of the sympathetic afferent nerve either inhibited or excited renal nerves and increased or decreased systemic blood pressure. The direction of these changes depended on stimulus parameters. No obligatory correlation in the direction of change of nerve activity and blood pressure was observed. Activation of cardiopulmonary sympathetic afferent nerves by intravascular volume expansion inhibited renal nerve discharge. Inhibition was elminated by sectioning the sympathetic afferent nerves. Volume expansion had no effect on lumbar sympathetic discharge monitored simultaneously with renal nerve activity. This observation suggests specificity of reflex influences of these afferent nerves on the kidney. In conclusion, cardiopulmonary sympathetic afferent nerves can reflexly alter renal nerve activity, and therefore may affect renal control of intravascular volume.
心肺交感传入神经可能通过影响肾交感神经活动来影响肾脏对血管内容量的调控。在使用α-氯醛糖麻醉、切断迷走神经、切除窦神经和主动脉神经的猫身上评估了这种影响。当用单个电刺激激活传入神经时，肾神经会以兴奋性活动爆发作为反应，随后是长时间的抑制。这种反应具有脊髓上反射的特征。重复刺激交感传入神经会抑制或兴奋肾神经，并升高或降低全身血压。这些变化的方向取决于刺激参数。未观察到神经活动和血压变化方向之间的必然相关性。血管内容量扩张激活心肺交感传入神经会抑制肾神经放电。切断交感传入神经可消除这种抑制。容量扩张对与肾神经活动同时监测的腰交感神经放电没有影响。这一观察结果表明这些传入神经对肾脏的反射影响具有特异性。总之，心肺交感传入神经可反射性改变肾神经活动，因此可能影响肾脏对血管内容量的调控。
