Meckler R L, Macklem L J, Weaver L C
Am J Physiol. 1981 Nov;241(5):R267-70. doi: 10.1152/ajpregu.1981.241.5.R267.
Cardiac sympathetic afferent nerves can reflexly alter renal efferent nerve activity during myocardial ischemia and in response to mechanical or chemical stimulation of cardiac receptors. They also may influence renal excretion of water and electrolytes; however, this potential influence on renal function has not been determined. Therefore, receptors of cardiac sympathetic afferent nerves were chemically stimulated by epicardial application of bradykinin to determine effects on renal function. Experiments were performed in anesthetized dogs in which cervical vagosympathetic trunks were severed and common carotid arteries were tied to diminish influences of arterial baroreceptors and vagal afferent nerves. Chemical stimulation of cardiac afferent neurons excited renal nerve activity and produced decreases in urine flow rate, glomerular filtration rate, and excretion of sodium and potassium. In contrast, no consistent changes in renal function were observed in control dogs, which did not undergo cardiac afferent stimulation. These data provide evidence that activation of cardiac sympathetic afferent neurons can lead to alterations in excretion of water and electrolytes as well as changes in renal nerve activity.
心脏交感传入神经在心肌缺血期间以及对心脏感受器的机械或化学刺激作出反应时，可反射性改变肾传出神经活动。它们也可能影响水和电解质的肾排泄；然而，这种对肾功能的潜在影响尚未确定。因此，通过在心外膜应用缓激肽对心脏交感传入神经的感受器进行化学刺激，以确定其对肾功能的影响。实验在麻醉犬身上进行，切断颈迷走交感干并结扎颈总动脉，以减少动脉压力感受器和迷走传入神经的影响。对心脏传入神经元的化学刺激可兴奋肾神经活动，并使尿流率、肾小球滤过率以及钠和钾的排泄减少。相比之下，未接受心脏传入刺激的对照犬未观察到肾功能的一致变化。这些数据证明，心脏交感传入神经元的激活可导致水和电解质排泄的改变以及肾神经活动的变化。
