大鼠杏仁基底外侧核对吗啡诱导的味觉回避的影响。
Basolateral amygdala and morphine-induced taste avoidance in the rat.
机构信息
University of Illinois at Chicago, Biologic Resources Laboratory, 1840 West Taylor St, Chicago, IL 60612, USA.
出版信息
Physiol Behav. 2010 Mar 3;99(3):419-23. doi: 10.1016/j.physbeh.2009.12.007. Epub 2009 Dec 13.
The present experiment examined the influence of excitotoxic lesions of the basolateral amygdala (BLA) on morphine-induced saccharin avoidance. Neurologically intact subjects rapidly learned to avoid drinking the taste conditioned stimulus (CS), an effect that was sustained throughout the experiment. Although the BLA-lesioned (BLAX) rats showed CS avoidance over the first few trials, the effect was not sustained. That is, by the end of the experiment, the BLAX rats were drinking the same amount of saccharin after seven saccharin-morphine trials as they did on the first trial (i.e., prior to the morphine injections). Potential interpretations of the results are discussed including a disruption of the mechanism that governs drug-induced taste avoidance in normal subjects and the more rapid development of tolerance in BLAX rats.
本实验研究了外侧杏仁核（BLA）兴奋毒性损伤对吗啡诱导的蔗糖回避的影响。神经完整的实验对象迅速学会了回避饮用味觉条件刺激（CS），这种效果在整个实验过程中得以维持。尽管 BLA 损伤（BLAX）大鼠在最初几次试验中表现出 CS 回避，但这种效果并未持续。也就是说，到实验结束时，BLAX 大鼠在经历了七次蔗糖-吗啡试验后，饮用的蔗糖量与第一次试验（即在接受吗啡注射之前）相同。对结果的潜在解释包括：正常受试者中控制药物诱导味觉回避的机制受到破坏，以及 BLAX 大鼠更快地产生了耐受。
Zotero 插件