大鼠岛叶皮质损伤与吗啡诱导的条件性刺激摄取抑制
Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat.
作者信息
Roman Christopher, Reilly Steve
机构信息
Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA.
出版信息
Behav Neurosci. 2009 Feb;123(1):206-11. doi: 10.1037/a0014308.
Abstract
The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.
摘要
本实验在以吗啡作为无条件刺激的终结性程序中，研究了岛叶皮质（IC）损伤对味觉刺激摄入量的影响。在正常大鼠中，当味觉新颖时，吗啡会使糖精摄入量迅速减少，但当味觉熟悉时则不会。无论刺激是否新颖，吗啡对IC损伤大鼠的糖精消耗量影响很小。我们从以下两方面对结果进行了讨论：（i）损伤引起的奖励比较机制破坏；（ii）味觉新颖性的感知。
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