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猪和人 tetherin 对猪内源性逆转录病毒释放的调控。

Regulation of porcine endogenous retrovirus release by porcine and human tetherins.

机构信息

Wohl Virion Centre, Division of Infection and Immunity, University College London, London, United Kingdom.

出版信息

J Virol. 2010 Mar;84(5):2618-22. doi: 10.1128/JVI.01928-09. Epub 2009 Dec 16.

DOI:10.1128/JVI.01928-09
PMID:20015985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2820912/
Abstract

The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering.

摘要

猪内源性逆转录病毒（PERV）的传播风险是异种移植中的主要安全问题之一。最近被描述为一种能够抑制包膜病毒释放的抗病毒蛋白的人 tetherin 及其猪同源物被证明能够抑制生产者细胞中 PERV 的释放，它们本身成为通过动物工程抑制猪异种移植物中 PERV 产生的候选分子。

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2
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本文引用的文献

1
Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration.猿猴免疫缺陷病毒包膜糖蛋白通过细胞内隔离拮抗 tetherin/BST-2/CD317。
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20889-94. doi: 10.1073/pnas.0907075106. Epub 2009 Oct 28.
2
Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein.人类免疫缺陷病毒2型包膜糖蛋白对人束缚素的拮抗作用及细胞内隔离
J Virol. 2009 Nov;83(22):11966-78. doi: 10.1128/JVI.01515-09. Epub 2009 Sep 9.
3
Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs.表达猪内源性逆转录病毒小干扰RNA的转基因猪的培育。
Xenotransplantation. 2009 May-Jun;16(3):164-80. doi: 10.1111/j.1399-3089.2009.00525.x.
4
Nef proteins from simian immunodeficiency viruses are tetherin antagonists.来自猿猴免疫缺陷病毒的Nef蛋白是束缚素拮抗剂。
Cell Host Microbe. 2009 Jul 23;6(1):54-67. doi: 10.1016/j.chom.2009.05.008. Epub 2009 Jun 4.
5
Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.单个残基的突变使人类束缚素对HIV-1 Vpu介导的耗竭具有抗性。
PLoS Pathog. 2009 May;5(5):e1000443. doi: 10.1371/journal.ppat.1000443. Epub 2009 May 22.
6
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.猴免疫缺陷病毒Nef和人免疫缺陷病毒1型Vpu在克服由束缚素/BST2介导的限制作用中的种属特异性活性
PLoS Pathog. 2009 May;5(5):e1000429. doi: 10.1371/journal.ppat.1000429. Epub 2009 May 15.
7
Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation.猪内源性逆转录病毒在用于异种移植的多转基因猪中的分布与表达
Xenotransplantation. 2009 Mar-Apr;16(2):64-73. doi: 10.1111/j.1399-3089.2009.00515.x.
8
Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants.HIV-1 Vpu的物种特异性活性及束缚素跨膜结构域变体的正选择
PLoS Pathog. 2009 Feb;5(2):e1000300. doi: 10.1371/journal.ppat.1000300. Epub 2009 Feb 13.
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Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.埃博拉糖蛋白可拮抗由束缚素介导的丝状病毒出芽限制作用。
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2886-91. doi: 10.1073/pnas.0811014106. Epub 2009 Jan 28.
10
Inhibition of Lassa and Marburg virus production by tetherin.连接蛋白对拉沙病毒和马尔堡病毒产生的抑制作用。
J Virol. 2009 Mar;83(5):2382-5. doi: 10.1128/JVI.01607-08. Epub 2008 Dec 17.