猪和人 tetherin 对猪内源性逆转录病毒释放的调控。
Regulation of porcine endogenous retrovirus release by porcine and human tetherins.
机构信息
Wohl Virion Centre, Division of Infection and Immunity, University College London, London, United Kingdom.
出版信息
J Virol. 2010 Mar;84(5):2618-22. doi: 10.1128/JVI.01928-09. Epub 2009 Dec 16.
Abstract
The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering.
摘要
猪内源性逆转录病毒（PERV）的传播风险是异种移植中的主要安全问题之一。最近被描述为一种能够抑制包膜病毒释放的抗病毒蛋白的人 tetherin 及其猪同源物被证明能够抑制生产者细胞中 PERV 的释放，它们本身成为通过动物工程抑制猪异种移植物中 PERV 产生的候选分子。
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